PMID: 25773846Mar 17, 2015Paper

CT findings of persistent pure ground glass opacity: can we predict the invasiveness?

Asian Pacific Journal of Cancer Prevention : APJCP
Li-Heng LiuYong Huang

Abstract

To investigate whether CT findings can predict the invasiveness of persistent cancerous pure ground glass opacity (pGGO) by correlating the CT imaging features of persistent pGGO with pathological changes. Ninety five patients with persistent pGGOs were included. Three radiologists evaluated the morphologic features of these pGGOs at high resolution CT (HRCT). Binary logistic regression was used to assess the association between CT findings and histopathological classification (pre-invasive and invasive groups). Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of diameters. A total of 105 pGGOs were identified. Between pre-invasive (atypical adenomatous hyperplasia, AAH, and adenocarcinoma in situ, AIS) and invasive group (minimally invasive adenocarcinoma, MIA and invasive lung adenocarcinomas, ILA), there were significant differences in diameter, spiculation and vessel dilatation (p<0.05). No difference was found in air-bronchogram, bubble- lucency, lobulated-margin, pleural indentation or vascular convergence (p>0.05). The optimal threshold value of the diameters to predict the invasiveness of pGGO was 12.50mm. HRCT features can predict the invasiveness of persistent...Continue Reading

References

Apr 22, 2011·Journal of Thoracic Imaging·Ho Yun Lee, Kyung Soo Lee
Aug 24, 2013·The Annals of Thoracic Surgery·Sukki ChoSanghoon Jheon
Feb 22, 2014·AJR. American Journal of Roentgenology·Ho Yun LeeJung Won Moon

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Citations

Jun 4, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Benedikt H HeidingerAlexander A Bankier
Feb 9, 2018·Biomedical Engineering Online·Jing YangJiansong Ji

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