CT-guided aspiration lung biopsy for EGFR and ALK gene mutation analysis of lung cancer

Oncology Letters
Weisheng Lian, Yong Ouyang

Abstract

The present study investigated the rates of detection and the positive rates of computed tomography (CT)-guided aspiration of lung biopsy for epidermal growth factor receptor (EGFR) gene and anaplastic lymphoma kinase (ALK) gene, and analyzed the relationship between gene mutation and clinical characteristics to improve the rate of related factors of gene detection. The clinical data and CT-guided aspiration biopsy specimen of 250 patients with lung cancer. Data showed that the rate of EGFR gene mutation was 41.2% (103/250) in biopsy specimens of non-small cell lung cancer patients. The rate of EGFR gene mutation of adenocarcinoma (56.6%, P<0.01) was higher than other types of lung cancer. ALK gene mutation of patients in phase IV was obviously higher than that of patients not in phase IV (18.5 and 1.8%, P<0.01). The rate of EGFR gene detection was 83.2% (208/250). The rate of detection of tumor cells >50 was higher. The rate of ALK protein immunohistochemical detection was 87.2%, and the rate of coarse needle biopsy detection was higher than that of the fine needle (91 and 72%, P<0.01), but the positive rate between coarse needle biopsy and fine needle biopsy had no difference (P>0.05). The rate of detection was associated wit...Continue Reading

References

Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valentina DonatiRami Ishaq Aqeilan
May 22, 2007·Lancet·Brian P RubinChristopher L Corless
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George SimonGerold Bepler
Mar 14, 2008·The New England Journal of Medicine·Fortunato Ciardiello, Giampaolo Tortora
Feb 24, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kentaro InamuraYuichi Ishikawa
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
May 26, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C SoriaT Le Chevalier
Oct 12, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuichi SakairiHideki Kimura
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Feb 1, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Eunhee S YiPing Yang
May 25, 2012·Cleveland Clinic Journal of Medicine·Patrick C Ma
May 25, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·June Koo LeeYung-Jue Bang
Aug 2, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J YingN Lu
Dec 20, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Justin F GainorAlice T Shaw
Aug 15, 2015·Thoracic Cancer·Wanqing ChenSiwei Zhang

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

SPSS

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