CT-guided interstitial brachytherapy in the local treatment of extrahepatic, extrapulmonary secondary malignancies.

European Radiology
Gero WienersJens Ricke

Abstract

The purpose was to evaluate the safety and efficacy of high-dose-rate (HDR) CT-guided interstitial brachytherapy in the treatment of extrahepatic, extrapulmonary, secondary malignancies. Nineteen patients were included in this prospective study. The median age was 66 years (49-77). Underlying primaries comprised colorectal carcinomas in six, renal cell carcinoma in three, pancreatic carcinoma in three, cervical cancer in two, endometrial cancer in two and NSCLC, breast cancer and sarcoma in one patient each. All patients had undergone extensive pretreatments. CT-guided HDR brachytherapy employed a 192Iridium source. Dose planning for brachytherapy was performed using 3D CT data acquired after CT-guided percutaneous applicator positioning. MRI follow-up was performed 6 weeks and every 3 months post intervention. Primary endpoints were complications, local tumor control and progression-free survival. The median tumor diameter was 6 cm (2-15 cm). Tumor locations included the hepatoduodenal ligament, mesentery, adrenal gland, mesogastrium and local recurrences after rectal or pancreatic cancer. The minimal median dose in the target volume was 11 Gy (4-18 Gy). Minor complications comprised pain and fever (n=6, 32%). Major complicati...Continue Reading

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Citations

Jan 18, 2012·Der Radiologe·T BretschneiderJ Ricke
Jul 31, 2012·Journal of Radiation Research·Kazushi KishiNoboru Yamanaka
May 11, 2013·The British Journal of Radiology·F CollettiniB Gebauer
Jan 25, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nikolaos TselisNikolaos Zamboglou
Sep 24, 2011·Seminars in Radiation Oncology·Jens Ricke, Peter Wust
Jan 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Konrad MohnikeJens Ricke
Apr 19, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gero WienersJens Ricke
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