CT-guided percutaneous lung biopsies in patients with haematologic malignancies and undiagnosed pulmonary lesions

Hematological Oncology
Sanjay GuptaMarshall E Hicks

Abstract

We searched the electronic patient database at The University of Texas M. D. Anderson Cancer Center for patients who underwent computed tomography (CT)-guided needle biopsy between January 2001 and December 2005. Inclusion criteria were a known history of haematologic malignancy and a newly detected, undiagnosed pulmonary lesion on chest CT that required tissue sampling for diagnosis; 213 met these criteria. We analysed the biopsy results for diagnostic yield, factors affecting diagnostic yield and effect on treatment. Of 213 procedures, 191 (89.7%) yielded sufficient material for pathologic analysis; 130 (60%) yielded specific diagnoses, while 61 (28.6%) yielded nonspecific benign diagnoses. Lesions larger than 1 cm, cavitary lesions and lung masses were more likely to yield a specific diagnosis than were lesions smaller than 1 cm, lung nodules and consolidations. The most common specific diagnoses were malignancy (62.8%) and infection (34.3%). The latter was more common in patients with leukaemia, cavitary lung lesions or consolidations, active underlying malignancy, neutropenia, respiratory signs and symptoms and/or fever, bone marrow transplant recipients, and in patients receiving chemotherapy. Lung lesions discovered upon...Continue Reading

References

Mar 1, 1979·Chest·G P Bodey
Apr 1, 1977·International Surgery·W MannellaT Matsumoto
Nov 1, 1990·Chest·F L HildebrandH D Tazelaar
Aug 1, 1990·Journal of Pediatric Surgery·C L SnyderA S Leonard
May 1, 1989·The American Review of Respiratory Disease·J R CatterallJ S Remington
Dec 1, 1987·American Journal of Surgery·J H ThomasG E Pierce
May 1, 1987·AJR. American Journal of Roentgenology·L M PerlmuttN R Dunnick
Sep 1, 1980·Chest·M F Tenholder, R G Hooper
Jan 1, 1996·Leukemia & Lymphoma·N BerkmanA Polliack
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·Dorothy A WhiteR Downey
Aug 2, 2001·Journal of Pediatric Surgery·J C DunnJ L Grosfeld
Nov 8, 2001·Journal of Vascular and Interventional Radiology : JVIR·K M YeowH P Liu
Mar 6, 2002·Journal of Pediatric Surgery·Andrea Hayes-JordanStephen J Shochat
Dec 3, 2005·Proceedings of the American Thoracic Society·Ladina Joos, Michael Tamm
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Apostolia-Maria TsimberidouMichael J Keating

Citations

Dec 7, 2013·Best Practice & Research. Clinical Haematology·Dimitrios P Kontoyiannis
Jan 14, 2011·European Journal of Radiology·Jens C RumpUlf K M Teichgräber
May 17, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MaschmeyerInfectious Diseases Working Party of the German Society of Hematology and Medical Oncology
Jul 20, 2019·American Journal of Hematology·Francesco MarchesiSorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) Group

Related Concepts

Biopsy
Solitary Pulmonary Nodule
Lung
Lung Diseases
Lung Diseases, Fungal
Malignant Neoplasm of Lung
Hematopoetic Myelodysplasia
Pneumocystis Jiroveci Pneumonia
Spontaneous Pneumothorax
Retrospective Studies

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.