CT Imaging Phenotypes of Pulmonary Fibrosis in the MUC5B Promoter Site Polymorphism.

Chest
Jonathan H ChungDavid A Lynch

Abstract

To determine the effect of the MUC5B promoter polymorphism (rs35705950) on the CT imaging appearance of pulmonary fibrosis. High-resolution CT scans of 1,764 subjects were scored as part of a, genomewide association study with institutional review board approval; 1,491 of these had pulmonary fibrosis on CT scans and were included in the study. Two thoracic radiologists independently scored CT scans systematically. Discrepancies were resolved by a third thoracic radiologist. All patients were genotyped specifically for the rs35705950 single-nucleotide polymorphism (SNP). Two-tailed Fisher exact or χ(2) tests and Student t tests or Mann-Whitney U tests were used to compare proportions and means, respectively. The major and minor alleles at the rs35705950 SNP are guanine (G) and thymine (T), respectively: 514 were homozygous for the major allele (G group), and 977 were heterozygous or homozygous for the minor allele (T group). The G group had a higher proportion than the T group with ground-glass opacity (62.1% vs 54.2%; P = .04). There was no significant difference between the G and T groups regarding presence of honeycombing. The T group showed a significantly higher subpleural axial distribution of fibrosis than did the G group...Continue Reading

References

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Citations

Dec 25, 2016·Journal of Medical Genetics·Paolo Spagnolo, Vincent Cottin
Apr 28, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Raphael BorieBruno Crestani
Mar 7, 2020·Expert Review of Respiratory Medicine·Federica Lo BelloGaetano Caramori
Oct 11, 2017·Frontiers in Medicine·Amarpreet KaurDavid A Schwartz
Jul 1, 2020·American Journal of Respiratory and Critical Care Medicine·Haruhiko FurusawaDavid A Schwartz

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