CT Radiogenomic Characterization of the Alternative Lengthening of Telomeres Phenotype in Pancreatic Neuroendocrine Tumors

AJR. American Journal of Roentgenology
Jonathan M McGovernAnil K Dasyam

Abstract

The objective of this study was to identify imaging characteristics in patients with known pancreatic neuroendocrine tumors (PanNETs) that predict the alternative lengthening of telomeres (ALT) phenotype by blinded retrospective review of preoperative multiphasic CT scans. For this retrospective study of 121 preoperative CT examinations of patients with resected PanNETs, two radiologists independently reviewed the CT examinations for tumor characteristics including size, shape, cystic or necrotic elements, calcifications, invasion of adjacent organs and vessels, biliary duct dilatation, pancreatic duct dilatation, and hepatic metastases. Univariate analysis of association of CT characteristics with ALT phenotype was performed with Fisher exact tests or t tests, and multivariate analysis was assessed by multiple logistic regression. Univariate analysis showed that the following CT features were significantly associated with the ALT phenotype: lobulated or irregular tumor shape (p = 0.001), tumor necrosis (p = 0.002), vascular invasion (p < 0.001), pancreatic duct dilatation (p < 0.001), and hepatic metastasis (p < 0.001). Multivariate analysis found that the combination of pancreatic duct dilatation, hepatic metastasis, and size...Continue Reading

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Citations

Oct 2, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Venkata S KatabathinaSrinivasa R Prasad
Aug 17, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lokesh KhannaVenkata S Katabathina
Oct 24, 2020·Abdominal Radiology·Mohammed SalehAjaykumar C Morani
Apr 10, 2021·European Journal of Nuclear Medicine and Molecular Imaging·C BezziM Picchio
Jun 3, 2021·Cancers·Danny MacKenzieDong Zhang

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