CT Radiomics Features in Differentiation of Focal-Type Autoimmune Pancreatitis from Pancreatic Ductal Adenocarcinoma: A Propensity Score Analysis.

Academic Radiology
Jing LiYun Bian

Abstract

To evaluate the diagnostic performance of the radiomics score (rad-score) for differentiating focal-type autoimmune pancreatitis (fAIP) from pancreatic ductal adenocarcinoma (PDAC). This retrospective review included 42 consecutive patients with fAIP diagnosed according to the International Consensus Diagnostic Criteria between January 2011 and December 2018. Furthermore, 334 consecutive patients with PDAC confirmed by pathology were also reviewed during the same period. Patients with PDAC and fAIP were matched via propensity score matching (PSM). All patients underwent multidetector computed tomography (MDCT). For each patient, 1409 radiomics features of the portal phase were extracted and reduced using the least absolute shrinkage and selection operator (LASSO) logistic regression algorithm. The portal rad-score performance was assessed based on its discriminative ability. After PSM, we matched 55 patients with PDAC to 42 patients with fAIP, based on clinical and CT characteristics (e.g., patient age, sex, body mass index, location, size, enhanced mode). A rad-score for discriminating fAIP from PDAC, which contained four CT derived radiomic features, was developed (area under the curve = 0.97). The sensitivity, specificity, a...Continue Reading

References

Jun 9, 2007·The American Journal of Gastroenterology·Amaar GhazaleMichael B Farnell
May 1, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Hye-Ryoun KimJae-Joon Yim
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Jun 1, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Christoph RehnitzLars Grenacher
May 9, 2012·World Journal of Gastroenterology : WJG·Taku TabataYoshihiko Inaba
Apr 25, 2014·AJR. American Journal of Roentgenology·Ashish KhandelwalSrinivasa R Prasad
Aug 12, 2014·European Radiology·Riccardo NegrelliRoberto Pozzi Mucelli
Dec 11, 2014·World Journal of Gastroenterology : WJG·Stefano CrosaraRoberto Pozzi Mucelli
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Dec 29, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Kazuichi OkazakiTooru Shimosegawa
Jun 29, 2017·Translational Oncology·Louisa BolmUlrich Friedrich Wellner
Sep 13, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Meghan G LubnerPerry J Pickhardt
Jan 13, 2018·Anesthesia and Analgesia·Steven J Staffa, David Zurakowski
Dec 5, 2018·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·K F Patrick TsangK Manu Nayar
Sep 8, 2019·Abdominal Radiology·Camila Lopes VendramiFrank H Miller
Oct 5, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Kristy Marie WolskeNeeraj Lalwani
Jul 7, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Kenji NotoharaKazuichi Okazaki

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