Cten signals through integrin-linked kinase (ILK) and may promote metastasis in colorectal cancer

Oncogene
Abdulkader AlbasriMohammad Ilyas

Abstract

CTEN/TNS4 is an oncogene in colorectal cancer (CRC), which can induce cell motility although its mechanistic basis of activity and the clinical implications of Cten expression are unknown. As Cten is in complex with integrins at focal adhesions, we hypothesised that it may interact with integrin-linked kinase (ILK). Through forced expression and knockdown of Cten in HCT116 and SW620 (respectively, showing low and high Cten expression), we showed that Cten could regulate ILK. However, inhibition of ILK after forced expression of Cten abrogated the motility-inducing effects of Cten, thereby demonstrating that the Cten-ILK interaction was functionally relevant. Combined knockdown of Cten and ILK had no additive effects on cell motility compared with knockdown of each individually. In order to investigate the clinical implications of Cten expression, a series of 462 CRCs were evaluated by immunohistochemistry. High expression of Cten was associated with advanced Dukes' stage (P<0.001), poor prognosis (P<0.001) and distant metastasis (P=0.008). The role of Cten in metastasis was tested by (a) intrasplenic injection of CRC cells stably transfected with a Cten expression vector into nude mice and (b) testing a series of primary human ...Continue Reading

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Citations

Feb 2, 2013·Cellular and Molecular Life Sciences : CMLS·Lui NgRoberta Pang
Apr 30, 2013·Molecular Carcinogenesis·Shih-Ya HungSu Hao Lo
Oct 29, 2014·International Journal of Experimental Pathology·Salih IbrahemMohammad Ilyas
Nov 22, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Youwei KouQiang Wang
Dec 5, 2013·Journal of Receptor and Signal Transduction Research·Lei XiaoQian Liu
Apr 17, 2014·The International Journal of Biochemistry & Cell Biology·Su Hao Lo
Jan 17, 2019·International Journal of Experimental Pathology·Abdulaziz AsiriMohammad Ilyas
Jun 23, 2020·International Journal of Experimental Pathology·Teresa P RaposoMohammad Ilyas
Feb 9, 2016·International Journal of Experimental Pathology·Hannah ThorpeMohammad Ilyas
Jun 19, 2013·Cancer Research·Shiao-Ya HongSu Hao Lo

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