CTL-associated and NK cell-associated immune responses induce different HBV DNA reduction patterns in chronic hepatitis B patients

Journal of Viral Hepatitis
Motonobu NomuraKazuaki Chayama

Abstract

The activation of hepatitis B virus (HBV)-related hepatitis is associated with both natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). We analyzed the association between the immune response and changes in the proportion of Pre-S deletion variants. We quantified Pre-S deleted HBV (HBV-del) and wild-type HBV (HBV-wt) DNA levels in sera obtained from HBV-infected mice and chronic hepatitis B patients. In chronic hepatitis B patients, the HBV-del proportion usually increased during or after ALT elevation but did not occur during all ALT elevations. To clarify this difference in the immunological responses, we performed in vivo analyses using HBV-infected human hepatocyte chimeric mice. Although HBV-del proportions did not change in mice with NK cell-associated hepatitis or in mice treated with entecavir, the proportions sharply increased in mice with CTL-associated hepatitis. Furthermore, the number of patients in which HBV-del proportions were greater than 5% was significantly higher in chronic hepatitis B patients than in asymptomatic carriers (P = 0.023). We identified associations between virological response in chronic hepatitis B patients and two different immune responses. The proportion of HBV-del variants could...Continue Reading

References

Jun 28, 2000·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C LoguercioC del VecchioBlanco
Aug 2, 2001·Nature Medicine·D F MercerN M Kneteman
Mar 5, 2003·Seminars in Liver Disease·Stephen LocarniniAngeline Bartholomeusz
Aug 28, 2004·The American Journal of Pathology·Chise TatenoKatsutoshi Yoshizato
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Masataka TsugeKatsutoshi Yoshizato
Sep 20, 2006·Antimicrobial Agents and Chemotherapy·Hiromi YatsujiKazuaki Chayama
Oct 16, 2007·Journal of Medical Virology·Hiromi YatsujiKazuaki Chayama
Jan 18, 2011·Biochemical and Biophysical Research Communications·Masami HasegawaHiroshi Suemizu
Feb 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akihito OkazakiKazuaki Chayama
Jun 6, 2012·Virology·Francois RedelspergerPatrick Soussan
May 8, 2014·Journal of Hepatology·Teresa PollicinoGiovanni Raimondo
Jul 15, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Xiaodong LiJin Li

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Citations

Sep 25, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Masataka Tsuge

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