CTLA-4 blockade with monoclonal antibodies in patients with metastatic cancer: surgical issues

Annals of Surgical Oncology
Giao Q PhanVernon K Sondak

Abstract

CTLA-4 (cytotoxic T lymphocyte-associated antigen 4) is a modulatory receptor on T cells involved in downregulating T cell activation. In animal models, CTLA-4 blockade abrogates tolerance to "self" antigens, resulting in the augmentation of antitumor immunity and induction of autoimmunity. CTLA-4 blockade by means of monoclonal antibodies (ipilimumab and tremelimumab) has been evaluated in multiple clinical trials in patients with metastatic cancer, mainly those with melanoma and renal cell cancer. We examine available literature and ongoing clinical trials with ipilimumab and tremelimumab and review our own experience with patients treated with CTLA-4 blockade, with an emphasis on issues of direct relevance to surgical oncologists. CTLA-4 blockade can cause durable tumor regression in patients with metastatic melanoma and other solid tumors. Grade III/IV autoimmune toxicity has been frequently encountered in clinical trials and includes enterocolitis, dermatitis, hypophysitis, uveitis, and hepatitis. Enterocolitis is the most common immune-related adverse event and may cause severe diarrhea requiring intravenous hydration, high-dose corticosteroids, and blockade of tumor necrosis factor alpha with infliximab. Most patients re...Continue Reading

References

Jun 15, 1990·Science·R H Schwartz
Sep 11, 1970·Science·P Bretscher, M Cohn
Mar 22, 1996·Science·D R LeachJ P Allison
Jun 1, 1996·The Journal of Experimental Medicine·M F Krummel, J P Allison
Jun 1, 1996·The Journal of Experimental Medicine·T L WalunasJ A Bluestone
Aug 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G Q PhanS A Rosenberg
Jan 25, 2002·European Journal of Immunology·Rebecca J GreenwaldArlene H Sharpe
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·F Stephen HodiGlenn Dranoff
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Giao Q PhanSteven A Rosenberg
Nov 10, 2004·Journal of Immunotherapy·Michael R RobinsonSteven A Rosenberg
Aug 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter AttiaSteven A Rosenberg
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antoni RibasJesus Gomez-Navarro
Feb 17, 2006·The New England Journal of Medicine·Helen GogasJohn M Kirkwood
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kimberly E BeckJames C Yang
Jun 27, 2006·Journal of Immunotherapy·Ajay V MakerSteven A Rosenberg
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Deirdre O'MahonyJohn E Janik
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric J SmallJames P Allison
Nov 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephanie G DowneySteven A Rosenberg
Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amod A SarnaikJeffrey S Weber

❮ Previous
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Citations

May 31, 2014·Journal of Surgical Case Reports·Lyle BurdineJonathan A Laryea
Jan 22, 2014·Nature Reviews. Clinical Oncology·Tara C Gangadhar, Robert H Vonderheide
Mar 29, 2014·The Journal of Clinical Investigation·Alena GrosSteven A Rosenberg
Oct 12, 2010·Clinical & Developmental Immunology·Joel F AldrichRonald C Kennedy
Sep 24, 2014·The Surgical Clinics of North America·Vernon K Sondak, Geoffrey T Gibney
Jan 5, 2010·Immunotherapy·Zhi-Qiang Huang, Donald J Buchsbaum
Jan 2, 2016·Journal of Crohn's & Colitis·Alexandre BalaphasFrédéric Ris
Apr 18, 2012·Expert Opinion on Biological Therapy·Carlo GenovaFrancesco Grossi
Oct 1, 2011·Advances in Surgery·Simon Turcotte, Steven A Rosenberg
May 3, 2011·Cytokine & Growth Factor Reviews·Marek JakobisiakWitold Lasek
Nov 30, 2010·Surgical Oncology Clinics of North America·Vernon K SondakRagini Kudchadkar
Dec 15, 2015·Immunotherapy·Dragoslav ZikichMichal J Besser
Sep 8, 2011·Journal of Cellular and Molecular Medicine·Yi WangXizhong Shen
Aug 23, 2011·Journal of Surgical Oncology·Vernon K SondakRagini Kudchadkar
Jun 4, 2013·Journal of Hepatology·Ye Htun Oo, Shimon Sakaguchi
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katarzyna D ChmielRichard Kefford
Jan 19, 2012·Clinical Medicine Insights. Oncology·Charlotte Lemech, Hendrik-Tobias Arkenau
Apr 23, 2009·British Journal of Cancer·S NizarA Dalgleish
May 1, 2018·Canadian Journal of Gastroenterology & Hepatology·Xianliang ChengYunqi Zhao
Mar 6, 2013·Melanoma Research·Cecile PagèsManuelle Viguier
Sep 10, 2020·Cancer Immunology, Immunotherapy : CII·Ali SafarzadehNicola Silvestris
Jun 27, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Giao Q PhanJonathan S Zager
Jun 4, 2015·Current Opinion in Gastroenterology·Edouard Louis
Feb 20, 2019·Journal for Immunotherapy of Cancer·Hao Chi ZhangYinghong Wang
Mar 22, 2014·The Annals of Pharmacotherapy·Steven P MerrillScott W Mueller
Nov 3, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William E Carson
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter A PrietoGiao Q Phan
Feb 26, 2021·Clinical Journal of Gastroenterology·Albert ChongMaha Guindi
Dec 26, 2009·Current Opinion in Obstetrics & Gynecology

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