PMID: 11606170Oct 19, 2001Paper

CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody

Diabetic Medicine : a Journal of the British Diabetic Association
T AbeK Eguchi

Abstract

The mode of onset is occasionally similar in Type 1 and Type 2 diabetes mellitus, and some patients with Type 2 diabetes are positive for antiglutamic acid decarboxylase antibody (GAD Ab). We investigated the contribution of Type 1 diabetes susceptibility genes to the progression of the insulin-deficient state and mode of onset of Type 2 diabetes in GAD Ab-positive (GAD-Ab+) patients. We examined the variable number of tandem repeats in the promoter region of the insulin gene (INS-VNTR, insulin-dependent diabetes mellitus (IDDM) 2) and cytotoxic T lymphocyte antigen 4 (CTLA4, IDDM12) as representative of Type 1 diabetes susceptibility genes. Patients with Type 2 diabetes who were GAD-Ab+ (n = 51) were selected for this study. In INS-VNTR, the class I allele was classified according to length (1S, 25-38 repeat units; 1M, 39-41 repeat units; 1L, 42-44 repeat units) and the exact class I allele length was analysed by specific polymerase chain reaction (PCR) amplifications. Analyses of classes II and III were performed by Southern blot. CTLA4 gene polymorphism (exon 1 position 49, G/A) was analysed by PCR-restriction fragment length polymorphism. The distribution of INS-VNTR was no different between Type 1 diabetes and Type 2 diabe...Continue Reading

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Mar 29, 2006·Diabetologia·E KawasakiK Eguchi
Jul 19, 2005·Human Genetics·Alexandra ZhernakovaBobby P C Koeleman
Jul 3, 2004·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Gloria Edith CerroneGustavo Daniel Frechtel
Aug 13, 2004·European Journal of Clinical Investigation·K HallerR Uibo
Oct 25, 2002·Diabetes/metabolism Research and Reviews·Norio AbiruKatsumi Eguch
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Pei-Wen WangChia-Ling Wu
Dec 25, 2008·The Journal of Clinical Endocrinology and Metabolism·Eiji KawasakiUNKNOWN Japanese Study Group on Type 1 Diabetes Genetics
Apr 3, 2012·The Journal of Clinical Endocrinology and Metabolism·Ichiro HorieAtsushi Kawakami

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