CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma

American Journal of Respiratory Cell and Molecular Biology
P PadridJ A Bluestone

Abstract

Complete T-cell activation requires two distinct signals, one delivered via the T-cell receptor, and the second "co-stimulatory" signal through CD28/B7 ligation. Previous studies showed that the blockade of CD28/B7 ligation alters differentiation of Th1/Th2 lymphocyte subsets in vitro and in vivo. The present study was designed to determine the effect of a CD28/B7 antagonist (CTLA4Ig) on Th1/Th2 development in Schistosoma mansoni-sensitized and airway-challenged mice. Treatment of mice with CTLA4Ig beginning 1 wk after sensitization abolished airway responsiveness to intravenous methacholine determined 96 h following antigen challenge. We also found a significant reduction in bronchoalveolar lavage (BAL) eosinophilia, and reduced peribronchial eosinophilic infiltration and mucoid-cell hyperplasia. Furthermore, CTLA4Ig treatment significantly decreased interleukin (IL)-4 and IL-5 content in BAL fluid in vivo, and the production of IL-5 by lung lymphocytes stimulated with soluble egg antigen (SEA) in vitro. In contrast, the content of interferon-gamma in BAL fluid and supernatant from SEA-stimulated lung lymphocytes from CTLA4Ig-treated mice was increased significantly compared with untreated animals. Thus, CTLA4Ig inhibits eosin...Continue Reading

References

Nov 1, 1992·The Journal of Experimental Medicine·P BraddingC H Heusser
Apr 1, 1990·The American Review of Respiratory Disease·C J Corrigan, A B Kay
Dec 1, 1990·Immunology Today·J R GordonS J Galli
Jun 1, 1988·Journal of Applied Physiology·T R MartinJ M Drazen
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O LeoJ A Bluestone
Aug 1, 1995·Current Opinion in Immunology·T A Wynn, A W Cheever
Aug 26, 1994·Science·B K FinckD Wofsy
Jan 1, 1995·American Journal of Respiratory and Critical Care Medicine·P PadridA R Leff
Mar 1, 1995·American Journal of Respiratory Cell and Molecular Biology·G BrusselleR Pauwels
Jun 1, 1994·American Journal of Respiratory Cell and Molecular Biology·S H GavettM Wills-Karp
Jan 1, 1994·American Journal of Respiratory and Critical Care Medicine·J SalogaE W Gelfand
May 1, 1994·American Journal of Respiratory Cell and Molecular Biology·N W LukacsS L Kunkel
Mar 1, 1996·International Archives of Allergy and Immunology·L B MartinG J Gleich
Dec 15, 1996·The Journal of Clinical Investigation·S J KrinzmanP W Finn
Jan 6, 1997·The Journal of Experimental Medicine·N HarrisF Ronchese
Oct 1, 1996·Immunological Reviews·A I Sperling, J A Bluestone
Feb 1, 1958·The American Journal of Physiology·M O AMDUR, J MEAD

❮ Previous
Next ❯

Citations

Jul 13, 2002·Pharmacology & Therapeutics·Y Riffo-Vasquez, D Spina
Dec 22, 1999·Microbes and Infection·J V WeinstockM Sandor
Aug 15, 2000·The International Journal of Biochemistry & Cell Biology·Y Riffo-VasquezD Spina
Nov 20, 2001·Current Opinion in Pharmacology·T J TorphyD E Griswold
Apr 4, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Svetlana P Chapoval, Chella S David
Aug 1, 2007·The Journal of Experimental Medicine·Hozefa S BandukwalaAnne I Sperling
May 17, 2000·Current Opinion in Pulmonary Medicine·M F Lipscomb, J A Wilder
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·M MathurP Padrid
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·A HaczkuE W Gelfand
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·J C KipsR A Pauwels
Sep 30, 1999·American Journal of Respiratory Cell and Molecular Biology·M MathurP Padrid
Mar 1, 2000·American Journal of Respiratory Cell and Molecular Biology·J M Green
May 15, 2001·American Journal of Respiratory Cell and Molecular Biology·J S BurrJ M Green
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·B U GajewskaM Jordana
Dec 1, 2001·American Journal of Respiratory Cell and Molecular Biology·D T DeurlooA J van Oosterhout
Mar 11, 2006·American Journal of Respiratory Cell and Molecular Biology·Ninghai WangPatricia W Finn
Oct 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Jiankun TongAnne I Sperling
Jan 3, 2001·Environmental Health Perspectives·W DongM I Gilmour
Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Christine M Deppong, Jonathan M Green
Oct 30, 2012·The Journal of Allergy and Clinical Immunology·Tea GogishviliThomas Hünig
Feb 19, 2008·Pharmacology & Therapeutics·Vipul V JainPatricia W Finn
Aug 4, 2009·Cellular Immunology·Rebecca A ShillingAnne I Sperling
Apr 19, 2006·The Journal of Experimental Medicine·Jiankun TongAnne I Sperling
Jun 25, 2010·Current Opinion in Pharmacology·Shyam S MohapatraGary Hellermann
Nov 8, 2016·PloS One·Leah R ReznikovMichael J Welsh
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D T Deurloo, A J M van Oosterhout
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K D YangC-L Wang
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K G TournoyR A Pauwels
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F K SwirskiM R Stämpfli
Aug 3, 2004·Journal of Applied Physiology·Richard LeighMark D Inman
Sep 7, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D P EnnisB P Mahon
Oct 14, 2006·European Journal of Immunology·Ian R HumphreysTracy Hussell
Oct 13, 2006·Clinical and Experimental Immunology·K NeuberM Weichenthal
Apr 26, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K D YangE-Y Huang
Sep 4, 2007·Nature Reviews. Immunology·Paolo Puccetti, Ursula Grohmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.