CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties

The Journal of Clinical Investigation
E ConseillerL Bracco

Abstract

The clinical potential of the p53 tumor suppressor gene is being evaluated currently for gene therapy of cancer. We have built a variant of wild-type p53, chimeric tumor suppressor 1 (CTS1), in which we have replaced the domains that mediate its inactivation. CTS1 presents some very interesting properties: (a) enhanced transcriptional activity; (b) resistance to the inactivation by oncogenic forms of p53; (c) resistance to the inactivation by MDM2; (d) lower sensitivity to E6-induced degradation; (e) ability to suppress cell growth; and (f ) faster induction of apoptosis. Thus, CTS1 is an improved tumor suppressor and an alternative for the treatment of wild-type p53-resistant human tumors by gene therapy.

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Citations

Nov 10, 2006·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·R D Meng, W S El-Deiry
Sep 24, 1999·Protein Science : a Publication of the Protein Society·E S StavridiT D Halazonetis
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Apr 13, 2004·Oncogene·Elizabeth A SleeXin Lu

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