CTX-M-14 and CTX-M-15 enzymes are the dominant type of extended-spectrum beta-lactamase in clinical isolates of Escherichia coli from Korea.

Journal of Medical Microbiology
Wonkeun SongHyo-Sun Kwak

Abstract

This study was performed to assess the prevalence and genotypes of plasmid-borne extended-spectrum beta-lactamases (ESBLs) and AmpC beta-lactamases in Escherichia coli in Korea. A total of 576 isolates of E. coli was collected from 12 Korean hospitals during May and July 2007. A phenotypic confirmatory test detected ESBLs in 82 (14.2 %) of the 576 E. coli isolates. The most common types of ESBLs identified were CTX-M-14 (n=32) and CTX-M-15 (n=27). The prevalence and diversity of the CTX-M mutants, including CTX-M-15, CTX-M-27 and CTX-M-57, with significant hydrolytic activity against ceftazidime were increased. PCR experiments detected genes encoding plasmid-borne AmpC beta-lactamases in 15/56 cefoxitin-intermediate or cefoxitin-resistant isolates, and the most common type of AmpC beta-lactamase identified was DHA-1 (n=10). These data suggest that the incidence of ESBLs in E. coli has increased as a result of the dissemination of CTX-M enzymes in Korea. In addition, CTX-M-22, CTX-M-27 and CTX-M-57 have appeared in Korea.

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Citations

Mar 8, 2012·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Wing Sze HoKwai Lin Thong
Aug 19, 2009·The Journal of Antimicrobial Chemotherapy·Peter M Hawkey, Annie M Jones
Feb 27, 2013·Antimicrobial Agents and Chemotherapy·Min-Su KangJun-Hun Kwon
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May 21, 2013·Journal of Chemotherapy·Carlo L RomanòLorenzo Drago
Mar 6, 2016·Journal of Medical Microbiology·Jarrad M HallTimothy J J Inglis
Apr 20, 2017·Drug Development and Industrial Pharmacy·Yagmur Akdag CayliLevent Oner
Feb 28, 2017·American Journal of Veterinary Research·Catherine VachonAllyson C Berent
Mar 26, 2015·Expert Review of Anti-infective Therapy·Hanna E Sidjabat, David L Paterson
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Apr 2, 2016·The Journal of Microbiology·Ji-Hoi MoonJin-Yong Lee
Dec 14, 2017·Scientific Reports·Fabíola CostaM Cristina L Martins
May 19, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jana MakhloufSima Tokajian
Sep 29, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kwang Gon KimTae Sun Kim

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Methods Mentioned

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PCR

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