Cu-Catalyzed selective cascade sp(3) C-H bond oxidative functionalization towards isoxazoline derivatives

Chemical Communications : Chem Comm
Gang-Wei WangShang-Dong Yang

Abstract

The first Cu-catalyzed cascade sp(3) C-H bond oxidative functionalization of the 2-ethylazaarenes has been developed. The two different sp(3) C-H bonds in 2-ethylazaarenes are selectively oxidized and four new types of bonds (C=O, C=N, C-C, C-O) are constructed in one operation. Starting from the simple substrates and cheap nitro source, this reaction provides an efficient approach to produce new kinds of isoxazolines.

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Citations

Mar 4, 2017·The Journal of Organic Chemistry·Tong-Yu FengJian-Ping Lang
Jan 23, 2019·Chemistry : a European Journal·Tobias BrandhoferOlga García Mancheño
Oct 10, 2019·Organic & Biomolecular Chemistry·Dahan WangGuo-Jun Deng

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