PMID: 8961300Nov 15, 1996Paper

Cu2+ potently enhances ATP-activated current in rat nodose ganglion neurons

Neuroscience Letters
C LiF F Weight

Abstract

Several lines of evidence suggest a physiological role for Cu2+ in regulating nervous system function. In the present study using whole-cell patch-clamp recording, Cu2+ greatly enhanced current activated by 10 microM ATP in the majority of rat nodose ganglion neurons. The enhancement was concentration-dependent between 1 and 50 microM Cu2+, and had an EC50 of 6.1 microM. Cu2+ shifted the ATP concentration-response curve to the left in a parallel manner. However, Cu2+ did not enhance ATP-activated current in the presence of a maximally-effective concentration of Zn2+. The observations suggest that Cu2+ increases the affinity of the receptor for ATP by acting at the Zn2+ modulatory site. In addition, a subset of neurons in the nodose ganglion express ATP-gated receptor-channels that are insensitive to modulation by physiological concentrations of Cu2+, Zn2+ and protons.

References

Aug 1, 1992·British Journal of Pharmacology·E M SilinskyS M Vanner
Jun 11, 1992·Nature·R J EvansA Surprenant
Aug 1, 1991·British Journal of Pharmacology·T G SmartR L Huganir
Jun 1, 1973·The Journal of General Physiology·A M Woodhull
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C LiF F Weight
Jul 1, 1993·Pflügers Archiv : European journal of physiology·R ClouesD A Brown
Apr 1, 1996·British Journal of Pharmacology·B F KingG Burnstock

❮ Previous
Next ❯

Citations

Jun 19, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yu-Wei LiuChao-Ying Li
Dec 28, 1999·Journal of Inorganic Biochemistry·C Exley
Jul 16, 1999·Neurochemistry International·F F WeightR W Peoples
Jul 23, 2002·Neuroscience Letters·Dian-Shi WangJi-Shuo Li
Jan 21, 2014·Progress in Neurobiology·Ivo F ScheiberRalf Dringen
Nov 12, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Fernando C OrtizJulio Alcayaga
Nov 19, 1997·Neuropharmacology·C VirginioA Surprenant
Jul 19, 2015·Neurochemistry International·Nadia D'Ambrosi, Luisa Rossi
Feb 15, 2015·Biochemical and Biophysical Research Communications·Yuwei LiuChao-Ying Li
Sep 25, 2002·Physiological Reviews·R Alan North
Mar 29, 2000·Journal of Neurochemistry·C Acuña-CastilloJ P Huidobro-Toro
May 13, 1999·Journal of Neurophysiology·K XiongC Li
Oct 16, 2001·Journal of Neurophysiology·M S Horning, P Q Trombley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
C LiF F Weight
Pflügers Archiv : European journal of physiology
R ClouesD A Brown
Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
R AldunateN C Inestrosa
© 2021 Meta ULC. All rights reserved