Cubic sub-20 nm NaLuF(4)-based upconversion nanophosphors for high-contrast bioimaging in different animal species

Biomaterials
Tianshe YangFuyou Li

Abstract

A new upconversion luminescence (UCL) nanophosphors based on host matrix of cubic NaLuF(4) with bright luminescence have been synthesized by a solvothermal method, facilitate the nanocrystals potential candidates for imaging in vivo, especially large-animals. The sub-20 nm NaLuF(4) co-doped Yb(3+) and Er(3+) (Tm(3+)) showed about 10-fold stronger UCL emission than that of corresponding hexagonal NaYF(4)-based nanocrystals with a 20 nm diameter. Near-infrared to near-infrared (NIR-to-NIR) UCL emission of PAA-coated NaLuF(4):20%Yb,1%Tm (PAA-Lu(Tm)) can penetrate >1.5 cm tissue of pork with high contrast. Based on super-strong UCL emission and deep penetration, PAA-Lu(Tm) as optical bioprobe has been demonstrated by in vivo UCL imaging of a normal black mouse, even rabbit with excellent signal-to-noise ratio. Furthermore, such cubic NaLuF(4)-based nanophosphor was applied in lymph node imaging of live Kunming mouse with rich white fur.

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Citations

Sep 28, 2013·Nature Protocols·Qian LiuFuyou Li
Jun 19, 2013·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Anne-Sophie ChauvinJean-Claude G Bünzli
Aug 15, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Juan OuyangMinghong Wu
Sep 27, 2012·Chemical Communications : Chem Comm·Daqin ChenYuansheng Wang
Jul 24, 2012·Advanced Drug Delivery Reviews·Miroslaw JanowskiPiotr Walczak
Dec 11, 2014·Chemical Reviews·Jing ZhouFuyou Li
Mar 13, 2014·Chemical Reviews·Guanying ChenXiaoyuan Chen
Aug 29, 2013·Advanced Materials·Wei FengFuyou Li
Jul 8, 2015·Chemical Reviews·Hao DongChun-Hua Yan
Dec 24, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Arik KarAmitava Patra
Mar 27, 2015·Macromolecular Rapid Communications·Ziyong Cheng, Jun Lin
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Feb 5, 2015·Annual Review of Physical Chemistry·Ling-Dong SunChun-Hua Yan
Aug 13, 2014·Chemical Society Reviews·Yun SunFuyou Li

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