Cubosomes and other potential ocular drug delivery vehicles for macromolecular therapeutics

Expert Opinion on Drug Delivery
Terence E HartnettKatharina Ladewig

Abstract

Many macromolecular therapeutics designed to treat posterior segment eye diseases (PSEDs) are administered through frequent ocular injection, which can further deteriorate eye health. Due to the high frequency of injection and the high cost of the therapeutics, there is a need to develop new ways in which to deliver these therapeutics: ways which are both safer and more cost effective. Using the most common PSED, age-related macular degeneration, as an example of a debilitating ocular disease, this review examines the key barriers limiting the delivery of macromolecular therapeutics to the posterior segment of the eye and defines the key requirements placed on particulate drug delivery vehicles (DDVs) to be suitable for this application. Recent developments in macromolecular drug delivery to treat this disease as well as the remaining shortcomings in its treatment are surveyed. Lastly, an emerging class of DDVs potentially suited to this application, called cubosomes, is introduced. Based on their excellent colloidal stability and high internal surface area, cubosomes hold great potential for the sustained release of therapeutics. Novel production methods and a better understanding of the mechanisms through which drug release f...Continue Reading

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Citations

Dec 15, 2015·Therapeutic Delivery·Intan D M AzmiAnan Yaghmur
Oct 30, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Simone AleandriEhud M Landau
Oct 6, 2016·Expert Opinion on Drug Delivery·Dunyin GuKatharina Ladewig
Oct 14, 2016·Journal of Microencapsulation·Juntao YinGuangxiu Lu
Nov 8, 2016·Drug Discovery Today·Krishna RadhakrishnanRupesh Agrawal
Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
May 23, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yong TianLingyi Sun
Jul 25, 2019·Pharmaceutics·Krishna RadhakrishnanSubbu Venkatraman

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