Cubosomes: remarkable drug delivery potential

Drug Discovery Today
Zahra Karami, Mehrdad Hamidi

Abstract

Cubosomes are nanostructured liquid crystalline particles, made of certain amphiphilic lipids in definite proportions, known as biocompatible carriers in drug delivery. Cubosomes comprise curved bicontinuous lipid bilayers that are organized in three dimensions as honeycombed structures and divided into two internal aqueous channels that can be exploited by various bioactive ingredients, such as chemical drugs, peptides and proteins. Owing to unique properties such as thermodynamic stability, bioadhesion, the ability of encapsulating hydrophilic, hydrophobic and amphiphilic substances, and the potential for controlled release through functionalization, cubosomes are regarded as promising vehicles for different routes of administration. Based on the most recent reports, this review introduces cubosomes focusing on their structure, preparation methods, mechanism of release and potential routes of administration.

References

Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D M AndersonS Leibler
Dec 1, 1965·Journal of the American Oil Chemists' Society·E S Lutton
Nov 11, 1999·International Journal of Pharmaceutics·Y Sadhale, J C Shah
Sep 6, 2000·Physical Review Letters·U S Schwarz, G Gompper
Apr 20, 2001·Advanced Drug Delivery Reviews·J C ShahD M Chilukuri
Feb 21, 2003·International Journal of Pharmaceutics·Jung Yoon UmSeo Young Jeong
Apr 11, 2003·Journal of Colloid and Interface Science·Matthew L LynchPatrick T Spicer
Jul 5, 2003·International Journal of Pharmaceutics·Ben J Boyd
Jun 17, 2004·AAPS PharmSci·Elisabetta EspositoRita Cortesi
Jul 21, 2004·Colloids and Surfaces. B, Biointerfaces·Warunee LeesajakulTetsurou Handa
Sep 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Greg A KossenaChristopher J H Porter
Jun 2, 2005·Journal of Colloid and Interface Science·Zhining WangTohru Inoue
Jun 22, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Johanna BenderJohan Moan
Jul 2, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·J Clogston, M Caffrey
Sep 15, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gert WörleHeike Bunjes
Nov 1, 2005·Journal of Colloid and Interface Science·Johanna BornéAli Khan
Apr 20, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Luciana B LopesM Vitória L B Bentley
Apr 28, 2006·Journal of the American Chemical Society·Borislav AngelovPatrick Couvreur
Jul 19, 2006·International Journal of Pharmaceutics·Manish H ShahAnant R Paradkar
Sep 22, 2006·International Journal of Pharmaceutics·G WörleH Bunjes
Mar 14, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Manish H Shah, Anant Paradkar
Dec 20, 2007·Molecular Cancer Therapeutics·Jung Wan HongHesson Chung
Jun 5, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Da DongBen J Boyd
Jun 10, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Johanna BenderMarica B Ericson
Sep 11, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Rivka EfratDganit Danino
Sep 23, 2008·Advances in Colloid and Interface Science·Anan Yaghmur, Otto Glatter
Mar 20, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Makoto UyamaTetsurou Handa
Apr 7, 2010·International Journal of Pharmaceutics·Teak Kwan Kwon, Jin Chul Kim
Apr 21, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Abid Riaz AhmedRoland Bodmeier
Jun 29, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Stefan SalentinigOtto Glatter
Oct 5, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ke HanChuanbin Wu

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Citations

Feb 14, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Jiali ZhaiCalum J Drummond
Feb 25, 2017·Chembiochem : a European Journal of Chemical Biology·Behnoosh Tajik-AhmadabadAnastasios Polyzos
Jan 5, 2017·Chemical & Pharmaceutical Bulletin·Md Ashraf AliShigeru Itai
Jun 22, 2018·Angewandte Chemie·Hanna M G BarrigaMolly M Stevens
Jul 16, 2019·The Journal of Pharmacy and Pharmacology·Seetha HarilalBijo Mathew
Jan 13, 2018·Therapeutic Delivery·Prit LakhaniSoumyajit Majumdar
Apr 22, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sébastien JenniClaudia Caltagirone
Jan 15, 2020·Current Pharmaceutical Design·Maryam ShabbirKashif Barkat
Jul 30, 2019·Critical Reviews in Analytical Chemistry·Bruno Vincenzo Fiod RiccioMarlus Chorilli
Sep 5, 2019·Pharmaceutics·Ángela Martin-SerranoF Javier de la Mata
Nov 16, 2019·International Journal of Molecular Sciences·Eliana B SoutoAmélia M Silva
Jan 17, 2020·Liquid Crystals Reviews·Marilyn Porras-Gomez, Cecilia Leal
Mar 29, 2020·Science China Materials·Congcong CuiLu Han
Aug 13, 2020·Drug Delivery and Translational Research·Mayra C G LotierzoLeandro R S Barbosa
Oct 5, 2019·Chemical & Pharmaceutical Bulletin·Makoto UyamaMinoru Nakano
Nov 24, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nada M El HoffySeham A Elkheshen
Jan 30, 2021·Drug Delivery·Sinar SayedOmnia Mohamed Khowessah
Sep 10, 2020·Heliyon·Abhinava GargGoutam Rath
Jan 12, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hussein AkelIldikó Csóka
Feb 11, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Carolina Del Valle BessoneDaniel Alberto Allemandi
Oct 30, 2020·International Journal of Nanomedicine·Dorota K FlakJanka Held-Feindt
Mar 4, 2021·Journal of Nanoscience and Nanotechnology·Sergio MurgiaClaudia Caltagirone
Mar 20, 2020·Progress in Materials Science·John R CleggNicholas A Peppas
Feb 8, 2021·International Journal of Pharmaceutics·Kang WangZhenbao Li
May 1, 2021·Pharmaceutics·Supandeep Singh HallanRita Cortesi
Jul 2, 2021·Frontiers in Cellular and Infection Microbiology·Antonio MorettaPatrizia Falabella
Jul 31, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tejashree WaghuleGautam Singhvi
Jul 17, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mohamed Fawzi KabilIbrahim M El-Sherbiny
Jul 10, 2017·ACS Biomaterials Science & Engineering·Niranjan G KotlaYury Rochev
Jan 7, 2017·ACS Central Science·Qi XiaoVirgil Percec
Nov 9, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Hanna M G BarrigaNicholas J Brooks
Nov 29, 2017·Bioconjugate Chemistry·Nicolas AlcarazBen J Boyd

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