Cubozoan crystallins: evidence for convergent evolution of pax regulatory sequences

Evolution & Development
Zbynek KozmikJoram Piatigorsky

Abstract

Cnidaria is the earliest-branching metazoan phylum containing a well-developed, lens-containing visual system located on specialized sensory structures called rhopalia. Each rhopalium in a cubozoan jellyfish Tripedalia cystophora has a large and a small complex, camera-type eye with a cellular lens containing distinct families of crystallins. Here, we have characterized J2-crystallin and its gene in T. cystophora. The J2-crystallin gene is composed of a single exon and encodes a 157-amino acid cytoplasmic protein with no apparent homology to known proteins from other species. The non-lens expression of J2-crystallin suggests nonoptical as well as crystallin functions consistent with the gene-sharing strategy that has been used during evolution of lens crystallins in other invertebrates and vertebrates. Although nonfunctional in transfected mammalian lens cells, the J2-crystallin promoter is activated by the jellyfish paired domain transcription factor PaxB in co-transfection tests via binding to three paired domain sites. PaxB paired domain-binding sites were also identified in the PaxB-regulated promoters of the J1A- and J1B-crystallin genes, which are not homologous to the J2-crystallin gene. Taken together with previous stud...Continue Reading

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Citations

Sep 29, 2009·Die Naturwissenschaften·Simon Conway Morris
Sep 2, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Pavel Vopalensky, Zbynek Kozmik
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May 10, 2017·Development Genes and Evolution·Aaron L StahlTiffany A Cook

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