CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?

Cell Research
Yongchao Zhao, Yi Sun

Abstract

CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.

References

Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Feb 10, 2007·Pharmacology & Therapeutics·Claire Gavériaux-Ruff, Brigitte L Kieffer
Jun 26, 2007·Molecular Cell·Jennifer Lee, Pengbo Zhou
Jan 17, 2008·European Journal of Human Genetics : EJHG·Pietro ChiurazziGiovanni Neri
Apr 11, 2009·Nature·Teresa A SoucySteven P Langston
Oct 13, 2009·Trends in Biochemical Sciences·Sarah Jackson, Yue Xiong
Jun 16, 2010·Genome Research·Brian J CoxJanet Rossant
Feb 5, 2011·Developmental Biology·Dragana KopanjaPradip Raychaudhuri

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Citations

Oct 6, 2015·Biomolecules·Dudley Chung, Graham Dellaire
May 21, 2021·The Tohoku Journal of Experimental Medicine·Chao ZhangPei Liu
Aug 11, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Wei-Qing LiZhi Zhu

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