Culex tarsalis is a competent vector species for Cache Valley virus.

Parasites & Vectors
Victoria B AyersDana L Vanlandingham

Abstract

Cache Valley virus (CVV) is a mosquito-borne orthobunyavirus endemic in North America. The virus is an important agricultural pathogen leading to abortion and embryonic lethality in ruminant species, especially sheep. The importance of CVV in human public health has recently increased because of the report of severe neurotropic diseases. However, mosquito species responsible for transmission of the virus to humans remain to be determined. In this study, vector competence of three Culex species mosquitoes of public health importance, Culex pipiens, Cx. tarsalis and Cx. quinquefasciatus, was determined in order to identify potential bridge vector species responsible for the transmission of CVV from viremic vertebrate hosts to humans. Variation of susceptibility to CVV was observed among selected Culex species mosquitoes tested in this study. Per os infection resulted in the establishment of infection and dissemination in Culex tarsalis, whereas Cx. pipiens and Cx. quinquefasciatus were highly refractory to CVV. Detection of viral RNA in saliva collected from infected Cx. tarsalis provided evidence supporting its role as a competent vector. Our study provided further understanding of the transmission cycles of CVV and identifies C...Continue Reading

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Citations

Jun 30, 2019·Zoonoses and Public Health·Lisa WaddellBarbara Wilhelm
Jul 19, 2020·Scientific Reports·Yan-Jang S HuangStephen Higgs
Apr 12, 2020·Parasites & Vectors·Kevin K ChanSally L Paulson
Aug 2, 2019·Parasites & Vectors·Victoria B AyersDana L Vanlandingham

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Datasets Mentioned

BETA
KX100133.1
KX100134.1

Methods Mentioned

BETA
PCR

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