Abstract
In recent years, the utility of serum-based diagnostic testing for Lyme disease has improved substantially; however, recovery by culture of the bacterium from skin biopsies of suspected patients is still the only definitive laboratory test. Reinfection of patients has been assumed to occur but as yet has not been documented by serial isolates from the same person. We present a case of culture-confirmed reinfection of a patient in Menominee County, Michigan. Borrelia burgdorferi was isolated from the skin punch biopsy specimens during each episode of erythema migrans (EM) and was subjected to molecular strain typing, genetic analysis of two outer surface protein genes, protein profile analysis, and serum antibody response testing. Results show that these isolates are distinct strains of the bacterium and that the two episodes of EM were caused by independent infections. This report describes the documented, culture-confirmed reinfection of a human by two different strains of B. burgdorferi.
References
Oct 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R GustafsonM Granström
Feb 1, 1992·Journal of Clinical Microbiology·B W BergerL Coleman
Nov 1, 1989·Infection·V Preac-MursicJ Prokop
Aug 31, 1989·The New England Journal of Medicine·A C Steere
Aug 1, 1989·Journal of Clinical Microbiology·R J Sinsky, J Piesman
Oct 25, 1986·Lancet·H W PfisterG D Borasio
Aug 1, 1983·Infection and Immunity·A G BarbourW J Todd
Jun 18, 1982·Science·W BurgdorferJ P Davis
Dec 1, 1995·Infection and Immunity·W T Golde, M C Dolan
Nov 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M G StobierskiV Carlson
Aug 1, 1994·Infection and Immunity·D H PersingS W Barthold
Jul 1, 1994·Journal of Medical Entomology·E D WalkerR G McLean
Mar 1, 1994·Journal of Clinical Microbiology·H KuiperJ Dankert
Dec 1, 1993·Infection and Immunity·S J PadulaR W Ryan
Sep 1, 1993·Annals of the Rheumatic Diseases·C D RoseR A Doughty
Nov 1, 1993·Journal of Clinical Microbiology·J BelfaizaI S Girons
Aug 11, 1993·Nucleic Acids Research·T HongyoC M Weghorst
Mar 1, 1993·Infection·F StrleM Jereb
Jan 1, 1993·The Journal of Experimental Medicine·W T GoldeJ Piesman
Aug 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F StrleR N Picken
Mar 1, 1996·Journal of Clinical Microbiology·D S GuttmanD E Dykhuizen
Jul 15, 1997·Annals of Internal Medicine·J NowakowskiG P Wormser
Oct 8, 1997·Infection and Immunity·J PiesmanW T Golde
Citations
Sep 21, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert B Nadelman, Gary P Wormser
Apr 25, 2007·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Elisabeth Aberer
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine J HasteyNicole Baumgarth
Feb 17, 1999·The Veterinary Quarterly·K E HoviusD J Houwers
Nov 16, 2012·The New England Journal of Medicine·Robert B NadelmanGary P Wormser
Apr 22, 2015·PloS One·Artem S RogovskyyTroy Bankhead
Jan 24, 2014·Infection and Immunity·Christine J HasteyNicole Baumgarth
Apr 18, 2013·PloS One·Artem S Rogovskyy, Troy Bankhead
Nov 20, 2002·Infection and Immunity·David M RobertsRichard T Marconi
Jan 29, 2021·Clinical Microbiology Reviews·John A Branda, Allen C Steere