PMID: 9442488Jan 1, 1997Paper

Culture in the presence of sugars increases activity of multi-drug efflux transporter on Haloferax volcanii

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
S MiyauchiN Kamo

Abstract

We found that when a growth medium contained glucose, wild-type cells of Haloferax volcanii were able to grow even in the presence of doxorubicin (DOX), an anti-cancer reagent, whereas they usually cannot grow in its presence. The reason was that cells grown in the presence of glucose (glucose-grown cells) showed high multi-drug efflux activity even though the growth medium contained no DOX or substrates of the transporter. This transporter was ATP-driven and the elevation of efflux activity was not due to an increase in intracellular ATP contents. The activity was increased not only by glucose but also by sugars that could be metabolized.

References

Oct 5, 1992·Biochimica Et Biophysica Acta·S MiyauchiN Kamo
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·O Lomovskaya, K Lewis
Aug 21, 1992·Science·H C Neu
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A A NeyfakhL B Chen
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·L McMurryS B Levy

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