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Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

Nature Microbiology

Feb 13, 2018

Bradley M HoverSean F Brady

Abstract

Despite the wide availability of antibiotics, infectious diseases remain a leading cause of death worldwide 1 . In the absence of new therapies, mortality rates due to untreatable infections are predicted to rise more than tenfold by 2050. Natural products (NPs) made by cultured bacteri...read more

Mentioned in this Paper

Gram-Positive Bacteria
Calcium [EPC]
Cyclic Peptides
HEK293 Cells
Methicillin resistant Staphylococcus aureus (organism)
Calcium
Bacteriocidal Agents
Antibiotic throat preparations
Natural Products
Antifungal Antibiotics, Topical
559
76
27
633
1
2
Paper Details
References
  • References28
  • Citations22
123
  • References28
  • Citations22
123

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Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

Nature Microbiology

Feb 13, 2018

Bradley M HoverSean F Brady

PMID: 29434326

DOI: 10.1038/s41564-018-0110-1

Abstract

Despite the wide availability of antibiotics, infectious diseases remain a leading cause of death worldwide 1 . In the absence of new therapies, mortality rates due to untreatable infections are predicted to rise more than tenfold by 2050. Natural products (NPs) made by cultured bacteri...read more

Mentioned in this Paper

Gram-Positive Bacteria
Calcium [EPC]
Cyclic Peptides
HEK293 Cells
Methicillin resistant Staphylococcus aureus (organism)
Calcium
Bacteriocidal Agents
Antibiotic throat preparations
Natural Products
Antifungal Antibiotics, Topical
559
76
27
633
1
2

Feeds With Similar Papers

Multi-drug Resistance

Multi-drug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to multiple antimicrobial drugs. Discover the latest research on multi-drug resistance here.

Infectious Disease - Sequencing (ASM)

Infectious Disease Sequencing is a emerging field due to low-cost massively parallel sequencing and allows researchers to monitor outbreaks of infectious pathogens. Discover the latest research on Infectious Disease Sequencing here.

Related Papers

Journal of Industrial Microbiology & Biotechnology

Culture-independent discovery of natural products from soil metagenomes

Journal of Industrial Microbiology & BiotechnologyNovember 21, 2015
Micah KatzSean F Brady
Natural Product Reports

Actinomycetes: still a source of novel antibiotics

Natural Product ReportsAugust 19, 2017
Olga Genilloud
Paper Details
References
  • References28
  • Citations22
123
  • References28
  • Citations22
123

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