Culture-Negative intracerebral abscesses in children and adolescents from Streptococcus anginosus group infection: a case series

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Cathy A PettiMalliswari Challapalli

Abstract

We report the use of 16S ribosomal RNA gene amplification and sequencing to diagnose culture-negative intracerebral abscesses in younger patients. These 3 cases demonstrate the optimal application of gene sequencing from direct specimens for patients with negative culture results compromised by antibacterial therapy but histories highly suggestive of acute bacterial infection.

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