PMID: 11916130Mar 28, 2002Paper

Cultured human dermal papilla cells secrete a chemotactic factor for melanocytes

Journal of Dermatological Science
Ritsuro IdetaOhji Ifuku

Abstract

Large numbers of pigmented melanocytes are located in human hair follicles, predominantly around the dermal papillae, and the number of melanocytes and the melanogenic activity of the hair follicles are closely related to the hair cycle. We found that cultured human dermal papilla cells secreted a melanocyte chemoattractant into the medium. Skin fibroblasts also showed weak chemoattraction of melanocytes, while skin keratinocytes and melanocytes did not. Since this chemotactic activity was heat-and protease-sensitive and was present in the relatively high molecular weight fraction (130-200 kDa), it may be due to extracellular matrix (ECM) that proteins secreted from the cultured dermal papilla cells. This chemotactic signal between dermal papillae and melanocytes may control the localization and migration of hair melanocytes in vivo.

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Feb 16, 2000·The Journal of Investigative Dermatology. Symposium Proceedings·D J TobinR Paus
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Citations

Mar 14, 2012·Cellular and Molecular Life Sciences : CMLS·Jill Goldstein, Valerie Horsley
Apr 6, 2005·Audiology & Neuro-otology·Marcos Sanchez HankeJohanna M Brandner
Jun 27, 2013·PloS One·Penkanok SriwiriyanontSteven T Boyce
Jan 8, 2004·The Journal of Investigative Dermatology·Margarita IndelmanEli Sprecher
Jan 20, 2009·Cancer·Olga PozdnyakovaStephen Lyle
Dec 16, 2005·The Journal of Investigative Dermatology·Andreya SharovVladimir A Botchkarev
Nov 10, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Emi DikaFrancesca Farnetani

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