PMID: 6974951Apr 1, 1981Paper

Cultured human syncytiotrophoblasts synthesize pregnancy-specific beta-1-glycoprotein (SP1)

Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
M HeikinheimoH Bohn

Abstract

The synthesis of pregnancy-specific beta-1-glycoprotein (SP1) was studied in human syncytiotrophoblast cultures from first trimester placentas. Incorporation of 35S-methionine into SP1 was demonstrated by immunoprecipitation and polyacrylamide gel electrophoresis. In double diffusion the precipitation line of neosynthesized SP1 gave a reaction of complete immunological identity with maternal serum SP1. By indirect immunofluorescence intracellular SP1 was localised in the perinuclear region of the cells. The average rate of SP1 release into culture fluid was 600 ng/mg protein in 24 hours. On a molar basis the release of SP1 was 10 times less than that of human chorionic gonadotrophin (hCG). Our results demonstrate, for the first time, that cultured human syncytiotrophoblasts synthesis SP1 immunologically indistinguishable from placental SP1.

References

Aug 1, 1979·American Journal of Obstetrics and Gynecology·S W RosenS A Aaronson
Nov 1, 1979·British Journal of Obstetrics and Gynaecology·J G GrudzinskasT Chard
Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·M SeppäläE Engvall
Jul 15, 1972·American Journal of Obstetrics and Gynecology·J L VaitukaitisG T Ross
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Jan 15, 1980·American Journal of Obstetrics and Gynecology·M SeppäläE M Rutanen
Feb 1, 1980·The Journal of Clinical Endocrinology and Metabolism·P C AzerE Engvall

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