PMID: 8947314Nov 1, 1996Paper

Cultured postnatal rat medial septal neurons respond to acute ethanol treatment and nerve growth factor by changing intracellular calcium levels

Alcoholism, Clinical and Experimental Research
B WebbD W Walker

Abstract

Ethanol neurotoxicity results in the loss of neurons during the development of the nervous system. Nerve growth factor (NGF) can ameliorate the neurotoxic effects of ethanol (EtOH) in rat medial septal (MS) neurons. These experiments study the effects of EtOH and NGF on neuronal calcium (Ca2+) homeostasis in cultured postnatal day of birth (PO) rat MS neurons. Previously, we observed that EtOH and NGF modulate intracellular Ca2+ levels [Ca2+]i) in unstimulated and high potassium stimulated (30 mM KCl) cultured rat embryonic day 21 (E21) MS neurons (Webb et al., Brain Res 701:61-74, 1995). The purpose of the present study was to explore whether the effects of EtOH and NGF on Ca2+ homeostasis were altered by developmental stage. The hypotheses tested were the following: treatment with EtOH affects Ca2+ homeostasis in postnatal day of birth (PO) rat MS neurons by causing transient and persistent changes in [Ca2+]i; NGF modulates Ca2+ homeostasis in MS neurons by regulating [Ca2+]i; the action of NGF changes the response of MS neurons to EtOH, thus altering Ca2+ homeostasis; and that EtOH and/or NGF effects on Ca2+ homeostasis are developmentally regulated. Our results indicated that behaviorally relevant levels of EtOH caused a ra...Continue Reading

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Citations

May 24, 2003·Brain Research. Developmental Brain Research·Barbara WebbMarieta B Heaton
Jan 23, 1998·Alcoholism, Clinical and Experimental Research·B WebbD W Walker
Oct 8, 1999·Alcoholism, Clinical and Experimental Research·M J DruseJ L Eriksen
Mar 1, 2010·Environmental Toxicology and Pharmacology·Shanmugam Lakshmi Devi, Carani V Anuradha

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