Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity

Journal of Food Science
D MorshediHoracio Pérez-Sánchez

Abstract

Fibrillation of alpha-synuclein (α-SN) is a critical process in the pathophysiology of several neurodegenerative diseases, especially Parkinson's disease. Application of bioactive inhibitory compounds from herbal extracts is a potential therapeutic approach for this cytotoxic process. Here, we investigated the inhibitory effects of the Iranian Cuminum cyminum essential oil on the fibrillation of α-SN. Analysis of different fractions from the total extract identified cuminaldehyde as the active compound involved in the antifibrillation activity. In comparison with baicalein, a well-known inhibitor of α-SN fibrillation, cuminaldehyde showed the same activity in some aspects and a different activity on other parameters influencing α-SN fibrillation. The presence of spermidine, an α-SN fibrillation inducer, dominantly enforced the inhibitory effects of cuminaldehyde even more intensively than baicalein. Furthermore, the results from experiments using preformed fibrils and monobromobimane-labeled monomeric protein also suggest that cuminaldehyde prevents α-SN fibrillation even in the presence of seeds, having no disaggregating impact on the preformed fibrils. Structural studies showed that cuminaldehyde stalls protein assembly into ...Continue Reading

References

Jul 19, 2002·Nature·Hilal A LashuelPeter T Lansbury
Apr 2, 2004·The Journal of Biological Chemistry·Min ZhuAnthony L Fink
Jun 9, 2005·Protein Expression and Purification·Chunjuan HuangChih-chen Wang
Jul 20, 2005·Biochimica Et Biophysica Acta·Sharon M KellyNicholas C Price
May 10, 2006·Biochemistry·Masami MasudaMasato Hasegawa
May 31, 2008·Nature Structural & Molecular Biology·Dagmar E EhrnhoeferErich E Wanker
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Marçal VilarRoland Riek
Sep 9, 2008·Journal of Molecular Biology·Dong-Pyo HongVladimir N Uversky
Aug 5, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paula DesplatsSeung-Jae Lee
Nov 17, 2009·Biochemical and Biophysical Research Communications·Andreas S HillmerArmin Giese
Dec 1, 2009·Biochimica Et Biophysica Acta·Dina MorshediMohsen Nemat-Gorgani
Dec 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gonzalo R LambertoClaudio O Fernández
May 25, 2010·Journal of Food Science·Tolou AllahghadriShakiba Darvish Alipoor Astaneh
Feb 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Beate WinnerRoland Riek
Oct 26, 2011·Biochimica Et Biophysica Acta·Leonid BreydoVladimir N Uversky
Jan 24, 2012·The Journal of Biological Chemistry·Basir Ahmad, Lisa J Lapidus
Mar 1, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Shubhangi PrabhudesaiJeff M Bronstein
Mar 21, 2013·ACS Chemical Neuroscience·Pradeep K SinghSamir K Maji
Feb 26, 2014·The Journal of Biological Chemistry·Srabasti AcharyaLisa J Lapidus
Jun 17, 2014·Biochimica Et Biophysica Acta·Marco DiociaiutiFiorella Malchiodi-Albedi
Apr 4, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacqueline BurréThomas C Südhof

❮ Previous
Next ❯

Citations

Jun 18, 2016·Parkinson's Disease·Dina Morshedi, Mahour Nasouti
Apr 21, 2019·Journal of Neurochemistry·Amir Tayaranian MarvianTiago Fleming Outeiro
Mar 7, 2020·Biomolecules·Margaux TeilBenjamin Dehay
May 25, 2016·Journal of Cellular Biochemistry·Subramanian SuganyaAnand Anbarasu
Sep 19, 2019·Journal of Pesticide Science·Tao ZhangXiangdong Mei
Jun 7, 2019·The Journal of Pharmacy and Pharmacology·Michael Adu-FrimpongJiangnan Yu
Apr 4, 2019·Frontiers in Pharmacology·Hayate JavedShreesh Kumar Ojha
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd RashedDevi Nair Gunasegavan Rathi
May 18, 2021·Applied Microbiology and Biotechnology·Vlada B Urlacher, Katja Koschorreck
Sep 2, 2017·ACS Chemical Neuroscience·Enrico ZanforlinGiovanni Ribaudo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.