Cumulative childhood adversity and adult cardiometabolic disease: A meta-analysis

Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association
Karen P JakubowskiKaren A Matthews

Abstract

Adverse childhood experiences may be associated with cardiometabolic morbidity and mortality in adulthood. There is heterogeneity in this literature regarding the type of items in cumulative adversity indices, sample sizes, demographics, and covariates. The present review used quantitative meta-analysis to examine this association and potential moderators. Included studies had a measure of cumulative adversity (an index of at least 2 adverse childhood experiences from age 0 to 18) and a measure of cardiometabolic disease: cardiovascular disease (CVD) clinical outcomes (hypertension, coronary heart disease, ischemic heart disease, myocardial infarction, stroke, cerebrovascular disease) and metabolic outcomes (diabetes, metabolic syndrome) at age 18 or older. Given different interpretations of odds ratios (OR) versus hazard ratios (HR), effects were pooled separately. Overall, 9 HR studies (15 effects) based on 179,612 participants and 29 OR studies (62 effects) based on 247,393 participants were included. On the basis of retrospectively assessed adversity, combined studies showed a significant estimated effect of cumulative childhood adversity on adult cardiometabolic disease (HR = 1.42, 95% CI [1.20, 1.67]; OR = 1.36 [1.27, 1.4...Continue Reading

Citations

Feb 5, 2019·JAMA Internal Medicine·Rebecca C Thurston, Karen A Matthews
Feb 25, 2020·Annual Review of Clinical Psychology·Teresa E DanielsAudrey R Tyrka
Feb 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Steven W ColeKathleen Mullan Harris
Sep 19, 2020·Psychosomatic Medicine·Hua ChenKrisztina D László
Dec 2, 2020·Public Health Nutrition·Bruna Clemente CotaSylvia do Carmo Castro Franceschini
Apr 28, 2020·Brain, Behavior, and Immunity·Jennifer L SteelDavid A Geller
Feb 13, 2021·Journal of Midwifery & Women's Health·Jewel ScottLeigh Ann Simmons
May 7, 2020·Current Opinion in Cardiology·Andrew H Tran, Elaine M Urbina
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Apr 27, 2021·Evaluation and Program Planning·Deanne C TibbittsRyan D Bradley
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Jul 9, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Letícia WelserCézane Priscila Reuter
Aug 7, 2021·Healthcare·Federica GalliStefano Carugo
Oct 5, 2021·JAMA Pediatrics·Lucinda Rachel GrummittKatie A McLaughlin

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