Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates.

Transplantation Direct
Rhea A VarugheseLianne G Singer

Abstract

Despite comprehensive multidisciplinary candidacy assessments to determine appropriateness for solid organ transplantation, limitations persist in identifying candidates at risk of adverse outcomes. Frailty measures may help inform candidacy evaluation. Our main objective was to create a solid organ transplant frailty index (FI), using the cumulative deficits model, from data routinely collected during candidacy assessments. Secondary objectives included creating a social vulnerability index (SVI) from assessment data and evaluating associations between the FI and assessment, waitlist, and posttransplant outcomes. In this retrospective cohort study of solid organ transplant candidates from Toronto General Hospital, cumulative deficits FI and SVI were created from data collected during candidacy evaluations for consecutive kidney, heart, liver, and lung transplant candidates. Regression modeling measured associations between the FI and transplant listing, death or removal from the transplant waitlist, and survival after waitlist placement. For 794 patients, 40 variable FI and 10 variable SVI were created (258 lung, 222 kidney, 201 liver, and 113 heart transplant candidates). The FI correlated with assessment outcomes; patients w...Continue Reading

References

Mar 2, 1995·The New England Journal of Medicine·J M GuralnikR B Wallace
Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Jun 14, 2003·TheScientificWorldJournal·A B MitnitskiK Rockwood
Apr 7, 2004·Journal of the American Geriatrics Society·Luigi FerrucciUNKNOWN Interventions on Frailty Working Group
Jun 25, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Arnold B MitnitskiKenneth Rockwood
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Jan 10, 2006·Journal of the American Geriatrics Society·Arnold MitnitskiKenneth Rockwood
Mar 8, 2006·Mechanisms of Ageing and Development·Arnold MitnitskiKenneth Rockwood
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Rockwood, Arnold Mitnitski
May 22, 2008·PloS One·Melissa K AndrewKenneth Rockwood
Oct 2, 2008·BMC Geriatrics·Samuel D SearleKenneth Rockwood
Jun 1, 2010·Journal of the American College of Surgeons·Martin A MakaryLinda P Fried
Jun 1, 2010·Journal of the American Medical Directors Association·Robbert J J GobbensJos M G A Schols
Jul 31, 2010·Journal of the American College of Surgeons·Michael J EnglesbeChristopher J Sonnenday
Nov 9, 2010·Journal of the American Geriatrics Society·Meredith C MaselKenneth J Ottenbacher
Nov 26, 2010·Clinics in Geriatric Medicine·Kenneth Rockwood, Arnold Mitnitski
May 5, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Jan 31, 2012·Age and Ageing·Melissa K AndrewKenneth Rockwood
Sep 11, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M AbecassisK P High
Dec 25, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Greg A Knoll
Jun 5, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A McAdams-DeMarcoD L Segev
Sep 14, 2013·Journal of the American Geriatrics Society·Olga TheouKenneth Rockwood
Feb 4, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shannon M DunlaySudhir S Kushwaha
Jun 18, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C LaiK Covinsky
Nov 2, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A McAdams-DeMarcoD L Segev
Aug 11, 2015·American Journal of Respiratory and Critical Care Medicine·Jonathan P SingerDavid J Lederer
Sep 5, 2015·Australasian Journal on Ageing·Ruth E HubbardDavid W Johnson
Sep 12, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie W WangJennifer C Lai
Dec 19, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael E WilsonCassie C Kennedy
Jun 18, 2016·Journal of Alzheimer's Disease : JAD·Joshua J ArmstrongMelissa K Andrew
Sep 30, 2016·World Journal of Transplantation·Lisa WickersonSunita Mathur
Oct 26, 2016·Transplantation·Mara A McAdams-DeMarcoDorry L Segev
Mar 4, 2017·Biogerontology·A B MitnitskiK Rockwood
Apr 9, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Dmitry RozenbergLianne G Singer
Apr 20, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jennifer C LaiSandy Feng
Jul 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J NastasiD L Segev
Sep 9, 2017·Transplantation·Mara A McAdams-DeMarcoDorry L Segev
Oct 5, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bryon A TompkinsJoshua M Hare

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
José María Remes-TrocheMiguel Angel Valdovinos
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Randi J ParksSusan E Howlett
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Amy YorkeStacy O'Blenes
© 2021 Meta ULC. All rights reserved