PMID: 11925386Apr 2, 2002Paper

Cumulative delivery rates after ICSI in women aged >37 years

Human Reproduction
Kaan OsmanagaogluPaul Devroey

Abstract

Female patients aged >37 years have a poor prognosis after ICSI. To determine the cumulative delivery rates in these women by life-table analysis, 228 patients aged >37 years who had undergone a total of 437 ICSI cycles were analysed retrospectively. Only cycles in which fresh ejaculated sperm was used, and in which at least one oocyte was micro-injected, were analysed. The main outcome measure was cumulative rate of deliveries. Any delivery after 25 weeks gestation was included in the study. In women aged 38-39 years, the real cumulative delivery rate after two cycles was 21%, while the expected delivery rate was 26%. In patients aged 40-43 years, the real and expected cumulative delivery rates were 12 and 17% respectively after three cycles, when they reached a plateau. There was only one delivery in the age group >43 years, which consisted of 26 patients with 66 cycles. In women aged >37 years, an expected cumulative delivery rate of 30% may be obtained at the end of the fourth cycle. Women aged >43 years do not have a realistic chance of achieving a delivery with their own oocytes. This life-table analysis provides a means by which to counsel couples about their chances of achieving a delivery by ICSI at an age >37 years.

Citations

Dec 8, 2007·Journal of Assisted Reproduction and Genetics·Norbert GleicherDavid Barad
Aug 29, 2013·Journal of Assisted Reproduction and Genetics·Michaël De BruckerMichel Camus
May 29, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Kris PoppeDaniel Glinoer
Apr 17, 2009·Human Reproduction·Michaël De BruckerHerman Tournaye
Dec 20, 2011·Asian Journal of Andrology·Herman Tournaye
Feb 18, 2016·Archives of Gynecology and Obstetrics·Martin Alexander SchallerConstanze Banz-Jansen
Feb 17, 2007·Clinical Endocrinology·Kris PoppeDaniel Glinoer
May 29, 2003·The Journal of Urology·Peter N KolettisJohn R Burns
Mar 19, 2014·Reproductive Biomedicine Online·Michaël De BruckerHerman Tournaye
Nov 16, 2004·Revista do Hospital das Clínicas·Fábio Firmbach PasqualottoSami Arap
Jun 25, 2010·Endocrine Reviews·G E KrassasD Glinoer
Mar 1, 2008·Expert Review of Endocrinology & Metabolism·Gerasimos E KrassasAthina Kaprara
Jan 28, 2021·Medicina·Myrna Souraye Godines-EnriquezEnrique Reyes-Muñoz

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