PMID: 11323784Apr 27, 2001Paper

Cumulative exposure to styrene and visual functions

American Journal of Industrial Medicine
L CastilloD Mergler

Abstract

Results from a 1990-1992 longitudinal study of several reinforced plastics plants showed that for those workers whose styrene exposure had decreased, color vision (CV) improved; while near visual contrast sensitivity (CS) was poorer. In 1999, we retested these visual functions in 18 workers with good visual acuity. A cumulative exposure index (CEI), corrected for respirator use, was calculated for each worker. Intra-individual comparison of mandelic acid (MA) showed a significant decrease over time (Friedman; P = 0.015), but current values were not related to CEI. For CV, no significant difference was observed between 1992 and 1999; present results were not related to MA or CEI. The CS profile decreased over time, with significant differences at 3 cpd (Friedman; P < 0.05). CS did not vary with MA levels, but was significantly depressed at the intermediate frequencies among those in the upper CEIH category (Kruskal-Wallis; P < 0.05). These findings suggest that CS loss increases with long-term cumulative exposure, reflecting chronic damage to the neuro-optic pathways.

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Citations

Aug 4, 2004·Neurotoxicology·Galina V ParameiAndreas Seeber
Aug 6, 2003·Neurotoxicology·Fabriziomaria Gobba, Alessandro Cavalleri
Jul 16, 2002·Environmental Health Perspectives·Judith S SchreiberJean C Parker
Dec 7, 2002·Occupational and Environmental Medicine·Y Y GongT Kawai
May 1, 2005·Environmental Toxicology and Pharmacology·Anders IregrenPer Nylén
Aug 26, 2015·American Journal of Industrial Medicine·Anna-Binney McCagueKathleen Kreiss
Jun 5, 2003·Environmental Health : a Global Access Science Source·Alberto Arnedo-PenaManolis Kogevinas
May 2, 2015·PloS One·Ingrid Astrid Jiménez BarbosaSieu K Khuu
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Apr 23, 2019·Environmental Health Perspectives·Emily J WerderLawrence S Engel
Mar 31, 2009·International Archives of Occupational and Environmental Health·Andreas SeeberGerhard Triebig

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