Cumulative False-Positive QuantiFERON-TB Interferon-γ Release Assay Results

Annals of the American Thoracic Society
Thomas E GamskyJon A Green

Abstract

Despite reports of unreliability, the QuantiFERON-TB interferon-γ release assay is increasingly used for the annual screening of individuals at risk for latent tuberculosis. Continued use of the QuantiFERON-TB assay suggests the need for more definitive evidence of its reproducibility and accuracy. To examine reproducibility and the accumulation of false-positive test results when the QuantiFERON-TB is repeated annually and to examine the validity of confirming positive test results with the performance of a second QuantiFERON-TB. We performed a retrospective, longitudinal evaluation of results from serial screening of a cohort of emergency responders from 2001 to 2013. Results of tuberculin tests and QuantiFERON-TB tests performed annually as part of a mandated first responder examination were retroactively reviewed. In this population, positive results occurred in new individuals each year. QuantiFERON-TB results were positive in 80 of 557 tuberculin test-negative individuals examined annually for a maximum of 7 years. Only 10 individuals with initially positive results remained positive when the test was repeated the next year, and 9 of these 10 were QuantiFERON-TB-negative within 3 years. The number of individuals with a po...Continue Reading

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Citations

Jul 9, 2016·Annals of the American Thoracic Society·Wendy T Thanassi, William G Buchta
Jul 9, 2016·Annals of the American Thoracic Society·L Masae Kawamura, T Warner Hudson
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Jul 7, 2018·Retinal Cases & Brief Reports·Edmund TsuiNaomi R Goldberg

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