Cumulative Histologic Inflammation Predicts Colorectal Neoplasia in Ulcerative Colitis: A Validation Study.

Inflammatory Bowel Diseases
Olivia V YvellezDavid T Rubin

Abstract

Chronic inflammation in ulcerative colitis (UC) is associated with the development of colorectal neoplasia (CRN). A group at St. Mark's Hospital reported a novel cumulative inflammatory index that predicted the development of CRN in UC patients that we validated with an independent, well-described, matched, case-controlled cohort from the University of Chicago. Cumulative inflammatory burden (CIB) was calculated by summing each histological inflammatory activity (HIA) score and multiplying it by the length of the surveillance interval. Persistency was defined by the number of surveillance episodes (with a severity score >2) divided by the total number of surveillance procedures. T tests compared the mean and maximum HIA scores, assessing mean and maximum severity, CIB, and persistency. Sixty-two UC patients (26 patients with CRN, 36 control patients without CRN) were analyzed. Fifty-five percent were men, mean disease duration was 20.6 years, and mean age at CRN diagnosis was 43.9. Of the CRN patients, 6 (23%) had colorectal cancer, 16 (62%) had low-grade dysplasia, and 4 (15%) had indefinite dysplasia. Using mean HIA scores, we found CIB to be statistically greater in CRN patients (P = 0.04). Using maximum HIA scores, we found...Continue Reading

References

Feb 6, 2004·Gastroenterology·Matthew RutterAlastair Forbes
Sep 18, 2010·Inflammatory Bowel Diseases·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Feb 1, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tine JessLaurent Peyrin-Biroulet
Jun 26, 2013·International Journal of Cancer. Journal International Du Cancer·Urpo NieminenMartti A Färkkilä
Jul 23, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David T RubinJerrold R Turner
Mar 7, 2019·The American Journal of Gastroenterology·David T RubinMillie D Long

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Citations

Jun 7, 2020·Journal of Crohn's & Colitis·Fernando MagroRoger Feakins
Jan 2, 2021·Gastroenterology·Anouk M WijnandsUNKNOWN Dutch Initiative on Crohn and Colitis (ICC)

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