PMID: 15231550Jul 3, 2004Paper

Cumulative incidence of mental disorders among offspring of mothers with psychotic disorder. Results from the Helsinki High-Risk Study

The British Journal of Psychiatry : the Journal of Mental Science
Laura T NiemiJouko K Lönnqvist

Abstract

The Helsinki High-Risk Study follows up all women born between 1916 and 1948 and treated for schizophrenia-spectrum disorders in psychiatric hospitals in Helsinki, their offspring born between 1960 and 1964, and controls. To determine the cumulative incidence of adulthood Axis I disorders among offspring. Using all hospital and out-patient treatment records we rediagnosed parents and offspring according to DSM-IV-TR criteria. Offspring were grouped by mother's diagnosis (schizophrenia n=104, schizoaffective disorder n=20, other schizophrenia-spectrum disorder n=30, and affective disorder n=25) and compared with a control group (n=176). The cumulative incidences of Axis I disorders among offspring were calculated. The cumulative incidences of any psychotic disorder were 13.5%, 10.0%, 10.0%, 4.0% and 1.1% among offspring of mothers with schizophrenia, schizo-affective disorder, other schizophrenia-spectrum disorders, affective disorders and controls, respectively. The corresponding figures for schizophrenia were 6.7%, 5.0%, 6.7%, 0% and 0.6%, and for any mental disorder 23.1%, 20.0%, 20.0%, 12.0% and 6.9%. Offspring of mothers with a psychotic disorder have heightened risk of developing a wide range of severe mental disorders.

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Citations

May 18, 2007·Psychological Medicine·J HaukkaJ Lönnqvist
Dec 1, 2007·Psychological Medicine·J SuvisaariJ Lönnqvist
May 21, 2005·The British Journal of Psychiatry : the Journal of Mental Science·S K Chaturvedi
Apr 3, 2007·European Archives of Psychiatry and Clinical Neuroscience·Angela Cristina Cesar TerzianJohn McGrath
Feb 19, 2010·Schizophrenia Research·Brian MillerBrian Kirkpatrick
Mar 10, 2016·Harvard Review of Psychiatry·Mohajer Abbass Hameed, Andrew James Lewis
Aug 3, 2007·Health & Place·Jan Saarela, Fjalar Finnäs
Jun 2, 2005·Schizophrenia Research·Laura T NiemiJouko K Lönnqvist
Jun 21, 2005·Schizophrenia Research·Mark WeiserShlomo Noy
Sep 23, 2011·Schizophrenia Research·Brian MillerBrian Kirkpatrick
Aug 2, 2014·Therapeutic Advances in Drug Safety·Megan GalballyJosephine Power
Feb 22, 2013·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Megan GalballyMartien Snellen
Mar 30, 2013·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Tom Fryers, Traolach Brugha
Oct 3, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Stephen J GlattMing T Tsuang
Feb 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Lauri T NiemiJouko K Lönnqvist
Jun 17, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Mary V Seeman
Sep 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Mark WeiserMichael Davidson

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