Cumulative incidence of post-infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis.

Influenza and Other Respiratory Viruses
Jonathan Nguyen-Van-TamRoman Fleischhackl

Abstract

Respiratory syncytial virus (RSV) infection is implicated in subsequent development of asthma/wheezing (AW) among term and pre-term infants. We describe the cumulative incidence of AW among hospitalized and ambulatory neonates/infants/toddlers following RSV infection diagnosis over three independent follow-up periods. Between January 1, 2007 and March 31, 2016, patients aged 0-2 years old with first clinical diagnosis of RSV infection were identified using the Optum® integrated electronic health records and claims database. Patients diagnosed with AW ≤ 30 days post-RSV diagnosis were excluded. Three cohorts with 1, 3, and 5 years of follow-up were stratified by presence or absence of specific RSV high-risk factors, including pre-term birth and pre-defined, pre-existing comorbidities. Descriptive statistics and logistic regression results were reported. Overall, 9811, 4524, and 1788 RSV-infected high-risk factor negative patients were included in 1, 3, and 5-year independent cohorts, respectively. Of these, 6.5%, 6.9%, and 5.8%, respectively had RSV-related hospitalization. By the end of follow-up, 14.9%, 28.2%, and 36.3% had AW events. Overall, 3030, 1378, and 552 RSV-infected high-risk factor positive patients were included in...Continue Reading

References

May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SigursB Kjellman
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Regis A VilchezShimon Kusne
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Aug 17, 2005·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·John HendersonHuw M Thomas
Feb 7, 2009·The New England Journal of Medicine·Caroline Breese HallPeter Szilagyi
Sep 13, 2011·Expert Review of Anti-infective Therapy·Pingsheng Wu, Tina V Hartert
Jan 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kim KristensenLone G Stensballe
Apr 5, 2012·Archives of Pediatrics & Adolescent Medicine·Jonathan M MansbachUNKNOWN MARC-30 Investigators
Jan 4, 2013·Paediatric Respiratory Reviews·Shelagh M SzaboAdrian R Levy
Oct 30, 2013·Journal of Medical Virology·Ikuko YuiTetsuo Nakayama
Oct 8, 2012·World Journal of Clinical Pediatrics·Bernhard Resch
Dec 3, 2014·Pediatrics in Review·Giovanni Piedimonte, Miriam K Perez
Feb 26, 2015·The New England Journal of Medicine·Seema JainUNKNOWN CDC EPIC Study Team
Feb 6, 2017·American Journal of Respiratory and Critical Care Medicine·Hiroyuki MochizukiUNKNOWN Scientific Committee for Elucidation of Infantile Asthma
Mar 4, 2018·The Lancet. Respiratory Medicine·Nienke M ScheltemaLouis J Bont
Jun 18, 2019·Influenza and Other Respiratory Viruses·Wei CaiSilke Buda

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