Cumulative incidence of radiation-induced cavernomas in long-term survivors of medulloblastoma

Journal of Neurosurgery
Sean M LewRick Abbott

Abstract

The goal of this study was to determine the incidence of radiation-induced cavernomas in children treated for medulloblastoma. A retrospective chart and film review was performed for all patients treated for medulloblastoma at the Insitute for Neurology and Neurosurgery/Beth Israel Medical Center between August 1996 and the present. The clinical and radiographic histories of pediatric patients (ages 3-21 years at diagnosis) with a histologically confirmed diagnosis of medulloblastoma who received craniospinal radiation therapy were reviewed. Fifty-nine patients were identified, with a mean age at radiation treatment of 7.7 years and a mean follow-up time of 7.2 years. The dose to the craniospinal axis was 24 Gy (31 patients) or 36 Gy (28 patients). The radiation energy in the craniospinal axis was provided by photons in 55 patients and protons in four. All patients received a posterior fossa boost of 54 Gy (46 patients) or 72 Gy (13 patients). Twenty-six lesions developed in 18 patients (31%) during the observation period. The cumulative incidence of lesion development was 5.6, 14, and 43%, at 3, 5, and 10 years, respectively. The sites of occurrence were cerebral (20 cases) and cerebellar (six cases). There was no significant ...Continue Reading

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Citations

Aug 2, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Fumiyuki YamasakiKaoru Kurisu
Mar 12, 2013·Seminars in Radiation Oncology·Thomas E Merchant
May 18, 2007·Neuro-Chirurgie·J Brunon, C Nuti
May 18, 2007·Neuro-Chirurgie·G LenaD Scavarda
Nov 26, 2009·Neurologic Clinics·Edward J Dropcho
Sep 21, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Li LiShoki Takahashi
Nov 4, 2008·Cancer Treatment Reviews·Piero FossatiRoberto Orecchia
Dec 7, 2007·Neuro-Chirurgie·A MelotF Proust
Jun 18, 2011·Epilepsy Research·Ramshekhar N MenonAshalatha Radhakrishnan
Feb 19, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Fumiyuki YamasakiKaoru Kurisu
Jul 28, 2013·AJNR. American Journal of Neuroradiology·D D M LinT O Crawford
Apr 6, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Fumiyuki YamasakiKaoru Kurisu
Sep 3, 2013·Journal of Neurosurgery. Pediatrics·Kristen W YeomMichael S B Edwards
Sep 3, 2010·Neurosurgical Focus·Adib A AblaRobert F Spetzler
Mar 30, 2012·Journal of Cardiovascular Translational Research·Daniel A MulrooneyDaniel Duprez

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Methods Mentioned

BETA
biopsy

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