Cumulative incidence, risk factors, and management of atrial fibrillation in patients receiving ibrutinib

Blood Advances
Tracy E WiczerFarrukh T Awan

Abstract

Atrial fibrillation (AF) has been reported in up to 16% of patients taking ibrutinib. Data regarding the management of AF in this patient population are limited, and stroke prevention poses a challenge because of increased risk of bleeding with ibrutinib treatment. Our study sought to describe the incidence of AF in adult patients treated with ibrutinib for a hematologic malignancy, assess management strategies, evaluate stroke and bleeding outcomes, and identify risk factors for occurrence. Of 582 patients treated with ibrutinib, 76 developed AF. With a median follow-up of 32 months, the estimated cumulative incidence at 6 months, 1 year, and 2 years was 5.9% (95% confidence interval [CI]: 4.2-8.0), 7.5% (95% CI: 5.5-9.9), and 10.3% (95% CI: 8.0-13.0), respectively. Median time to onset of AF was 7.6 months. History of AF and Framingham Heart Study (FHS) AF risk score were found to be significant risk factors for development of AF. Most patients were treated with rate control-only strategies (61.8%), and concomitant aspirin or anticoagulant therapy with ibrutinib was used in 52.6% and 28.9% of patients, respectively. One patient on aspirin developed symptoms consistent with stroke. Nine major bleeds were noted in 7 patients, a...Continue Reading

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Apr 22, 2005·Journal of Thrombosis and Haemostasis : JTH·S SchulmanUNKNOWN Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on T
Sep 16, 2009·Journal of Molecular and Cellular Cardiology·Jason PellmanFarah Sheikh
Apr 1, 2008·Circulation. Arrhythmia and Electrophysiology·Stanley NattelDobromir Dobrev
Jul 6, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Krekwit Shinlapawittayatorn, Isabelle Deschênes
Aug 2, 2011·The Journal of Clinical Investigation·Reza WakiliStanley Nattel
Jun 21, 2013·The New England Journal of Medicine·Michael L WangKristie A Blum
Jun 21, 2013·The New England Journal of Medicine·John C ByrdSusan O'Brien
Jun 3, 2014·The New England Journal of Medicine·John C ByrdUNKNOWN RESONATE Investigators
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Farrukh T Awan, John C Byrd
Apr 9, 2015·The New England Journal of Medicine·Steven P TreonRanjana H Advani
Jun 26, 2015·Scandinavian Journal of Immunology·A BerglöfC I E Smith
Jul 22, 2015·JAMA : the Journal of the American Medical Association·Eric N PrystowskyRichard I Fogel
Dec 8, 2015·The New England Journal of Medicine·Jan A BurgerUNKNOWN RESONATE-2 Investigators
Mar 20, 2016·American Journal of Hematology·Joshua N GustineJorge J Castillo
Apr 19, 2016·Leukemia & Lymphoma·Hun Ju LeePeter Kim
Oct 28, 2016·British Journal of Haematology·Philip A ThompsonFlorence Cymbalista

❮ Previous
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Citations

Nov 24, 2017·Frontiers in Immunology·Alexander N R WeberCornelia Brunner
Jan 13, 2018·Blood·Farrukh T Awan
May 9, 2018·Expert Review of Hematology·Farrukh T Awan, Wojciech Jurczak
Sep 19, 2019·British Journal of Haematology·Elizabeth M KanderTzu-Fei Wang
Feb 23, 2019·Journal of Community Hospital Internal Medicine Perspectives·Htay Htay KyiSamer Al Hadidi
Feb 8, 2019·Leukemia & Lymphoma·Robert LentzNausheen Akhter
Jul 26, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven P TreonJorge J Castillo
Nov 28, 2018·Drugs & Aging·Zeina Al-MansourVenu Bathini
Aug 16, 2019·Wiener klinische Wochenschrift·Markus C StühlingerMichael Steurer
Apr 3, 2020·American Society of Clinical Oncology Educational Book·Farrukh T AwanJennifer A Woyach
Jul 25, 2019·Hematological Oncology·Andrea VisentinLivio Trentin
Jun 7, 2019·Open Heart·Florian BaptisteFranck Thuny
May 15, 2020·Journal of Clinical and Experimental Hematopathology : JCEH·Kensuke Kojima, Jan A Burger
Jun 5, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Michael G FradleyMatthew B Schabath
Sep 2, 2020·Expert Review of Hematology·Praveen Ramakrishnan Geethakumari, Farrukh Awan
Sep 16, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven P TreonJorge J Castillo
Jul 28, 2020·Journal of the American Heart Association·Daniel AddisonHani Jneid
Nov 14, 2018·Biomedical Chromatography : BMC·Takeo YasuSeiichirou Kuroda
Mar 31, 2019·Targeted Oncology·Fabienne Lucas, Jennifer A Woyach
Jun 26, 2018·Current Heart Failure Reports·Zarina Sharalaya, Patrick Collier
Feb 20, 2018·Molecular Cancer·Simar Pal SinghRudi W Hendriks
Oct 13, 2018·European Cardiology·Athanasios KoutsoukisIoannis Paraskevaidis
Jun 13, 2018·Journal of Hematology & Oncology·Gianluigi RedaAgostino Cortelezzi
May 15, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Tienush RassafUNKNOWN Committee for Clinical Cardiovascular Medicine of the German Cardiac Society
Apr 2, 2020·Nature Reviews. Cardiology·Joerg Herrmann
Dec 5, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Rita Carlotta SantoroSimona Prejanò
Feb 4, 2021·Disease Markers·Ștefan SpînuAndrei Cosmin Cismaru
Dec 15, 2020·Platelets·Maan H HarbiMark R Thomas
Mar 31, 2021·Drugs·Danielle Wallace, Patrick M Reagan
Apr 30, 2021·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Denisa-Corina CiuculeteGheorghe-Andrei Dan
Dec 24, 2018·JACC. Clinical Electrophysiology·Sarju GanatraAnju Nohria
May 20, 2021·American Society of Clinical Oncology Educational Book·Stefanie L GroenlandVarsha Gandhi
Jun 18, 2021·Expert Opinion on Drug Safety·Magdalini MigkouMeletios Athanasios Dimopoulos

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