Cumulative live birth rates after IVF in patients with polycystic ovaries: phenotype matters

Reproductive Biomedicine Online
Michel De VosChristophe Blockeel

Abstract

Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment? In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed. After conventional ovarian stimulation using a gonadotrophin-releasing hormone antagonist protocol, the median number of oocytes retrieved ranged between 11 and 13.5 and did not differ significantly among the studied groups. Live birth rate (LBR) after fresh embryo transfer and CLBR after transfer of all fresh and vitrified embryos were significantly lower in women with hyperandrogenic PCOS phenotypes A (LBR 16.7%, CLBR 25.8%) and C (LBR 18.5%, CLBR 27.8%) compared with women with normoandrogenic PCOS phenotype D (LBR 33.7%, CLBR 48%) (P-value for LBR 0.01 and 0.03, respectively; P-value for CLBR 0.002 and 0.01, respectively) and controls with a polycystic ovarian morphology (LBR 37.1%, CLBR 53.3%) (P-value for LBR 0.002 and 0.01, respectively; P-value for CLBR <0.001 and 0.001, respectivel...Continue Reading

Citations

Sep 25, 2020·Paediatric and Perinatal Epidemiology·Elizabeth A DeVilbissEnrique F Schisterman
Jan 23, 2021·Clinical Obstetrics and Gynecology·Jessica R Zolton, Saioa Torrealday
Dec 11, 2020·Human Reproduction Update·Stefano PalombaLinda C Giudice
Jul 10, 2021·Reproductive Biomedicine Online·Alexandra L P Dietz de LoosJoop S E Laven
Jul 5, 2021·Journal of Assisted Reproduction and Genetics·Michel De VosRobert B Gilchrist

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