Cumulative Serum Uric Acid and Its Time Course Are Associated With Risk of Myocardial Infarction and All-Cause Mortality.

Journal of the American Heart Association
Xue TianYanxia Luo

Abstract

Background Serum uric acid (SUA) has been demonstrated as a risk factor for myocardial infarction (MI) and all-cause mortality; however, the impact of cumulative SUA (cumSUA) remains unclear. We aimed to investigate the association of cumSUA with MI risk and all-cause mortality, and to further explore the effects of SUA accumulation time course. Methods and Results The study enrolled 53 463 participants without a history of MI, and these participants underwent 3 examinations during 2006 to 2010. cumSUA from baseline to the third examination was calculated, multiplying mean values between consecutive examinations by time intervals between visits. Cox models estimated hazard ratios (HRs) and 95% CIs of MI and all-cause mortality for cumSUA quartiles, hyperuricemia exposure duration, and SUA accumulation time course. During a median follow-up of 7.04 years, 476 incident MIs and 2692 deaths occurred. In the fully adjusted model, a higher MI risk was observed in the highest cumSUA quartile (HR, 1.48; 95% CI, 1.10-1.99), in participants with longer hyperuricemia exposure duration (HR, 1.71; 95% CI, 1.06-2.73), and in participants with cumSUA≥median and a negative slope (HR, 1.58; 95% CI, 1.18-2.11). Similar associations persisted for...Continue Reading

References

Aug 1, 1997·Heart·S G WannametheeP H Whincup
Jul 3, 1999·Annals of Internal Medicine·B F CulletonD Levy
May 6, 2006·Stroke; a Journal of Cerebral Circulation·Michiel J BosMonique M B Breteler
Oct 28, 2008·European Journal of Endocrinology·Lucia PacificoClaudio Chiesa
Jan 17, 2014·European Journal of Preventive Cardiology·Sandip K ZalawadiyaLuis Afonso
Sep 10, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Paul ZemaitisHolly Kramer
Mar 31, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Ilia BeberashviliShai Efrati
May 22, 2017·Journal of the American College of Cardiology·Gregory A RothChristopher Murray
Oct 27, 2017·Journal of the American Heart Association·Aitian WangShike Hou
Mar 13, 2018·The New England Journal of Medicine·William B WhiteUNKNOWN CARES Investigators
May 11, 2018·Journal of Hypertension·Yasuo KansuiTakanari Kitazono
May 29, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gjin Ndrepepa
Sep 7, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naoyuki OtaniTeruo Inoue
Oct 28, 2019·The Journal of Clinical Endocrinology and Metabolism·Lihua HuXiaoshu Cheng
Feb 8, 2020·Atherosclerosis·Mohsen MazidiUNKNOWN Lipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group
Apr 1, 2020·Hypertension·Lisanne M JenkinsFarzaneh A Sorond

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Citations

Aug 3, 2021·Frontiers in Pharmacology·Hao-Lu SunJuan Jin

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