Cumulative use of salivary markers with an adaptive design improves detection of periodontal disease over fixed biomarker thresholds

Acta Odontologica Scandinavica
Ulvi K GursoyEija Könönen

Abstract

Aim was to analyze the diagnostic ability of cumulative risk score (CRS), which uses salivary levels of Porphyromonas gingivalis, interleukin (IL)-1β, and matrix metalloproteinase (MMP)-8 in an adaptive design, compared to previously reported thresholds of each marker alone. Oral and general health information of 463 participants were included in the analysis. Having the percentage of bleeding on probing (BOP) > 25%, having at least two sites with probing pocket depth (PPD) of 4-5 mm or having at least one tooth with alveolar bone loss (ABL) of at least 1/3 of the root length were accepted as outcome variables. Being above the salivary threshold concentrations of P. gingivalis, IL-1β, and MMP-8 and CRS values were used as explanatory variables. Receiver operating characteristics (ROC) producing an area under the curve (AUC) and multinomial regression analysis were used in statistical analysis. CRS provided AUCs larger than any other tested biomarker threshold. Sensitivity and specificity of CRS for detecting clinical markers of periodontitis were acceptable, and a strong association was observed between the highest CRS score and having at least two sites with PPD of 4-5 mm. CRS brings additional power over fixed thresholds of s...Continue Reading

References

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Oct 20, 2012·Journal of Clinical Periodontology·Ulvi K GursoyTimo Sorsa
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Jan 10, 2017·Frontiers in Cellular and Infection Microbiology·Ulvi K Gursoy, Eija Könönen
Feb 10, 2017·Journal of Dental Research·N M O'Brien-SimpsonE C Reynolds

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Citations

Oct 21, 2018·Journal of Clinical Periodontology·Ulvi K GürsoyTimo Sorsa
Mar 3, 2019·Journal of Clinical Periodontology·Sergio Iván Tobón-ArroyaveDiana María Isaza-Guzmán
Jul 25, 2019·Journal of Clinical Periodontology·Sergio Iván Tobón-ArroyaveAngye Alexandra Flórez-Alzate
Aug 4, 2020·Journal of Clinical Periodontology·Hyun-Duck KimYoung-Nim Choi
Dec 11, 2019·Journal of Clinical Medicine·Sanna SyrjäläinenEija Könönen
Jul 10, 2020·Clinical Oral Investigations·Çiğdem Yılmaz ŞaştımBaşak Doğan
Aug 9, 2020·Diagnostics·Joonas LiukkonenPirkko J Pussinen
May 19, 2021·BMC Oral Health·Yong ZhangYu Cai

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