Cumulus-oocyte complex interactions during oocyte maturation

International Review of Cytology
Masaki Yokoo, Eimei Sato

Abstract

In most mammals, the oocyte in the Graafian follicle is surrounded by tightly packed layers of cumulus cells, forming the cumulus-oocyte complex. During the preovulatory period, cumulus cells change from a compact cell mass into a dispersed structure of cells for the synthesis and deposition of a mucoid intercellular matrix, a process referred to as cumulus expansion. Cumulus expansion is thought to influence a variety of fundamental developmental changes during oocyte maturation. Volumetric expansion of the cumulus-oocyte complex correlates, at least in pig, with the outcome of oocyte maturation, fertilization, and embryo development. Therefore, detailed functional studies of cumulus expansion seem to be required to elucidate the mechanism of oocyte maturation. We summarize the current knowledge about (1) morphological changes of cumulus-oocyte complexes during oocyte maturation, (2) follicle factors inducing cumulus expansion, (3) the role of cumulus expansion in oocyte maturation, (4) cytoplasmic regulators of oocyte maturation, and (5) possible roles of cumulus expansion.

Citations

Mar 6, 2010·The Journal of Reproduction and Development·Masaki YokooEimei Sato
Mar 1, 2014·Animal Reproduction Science·Alma Álvarez-GuerreroNorma Moreno-Mendoza
Jul 4, 2017·Zygote : the Biology of Gametes and Early Embryos·Joanna BudnaBartosz Kempisty
Aug 21, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Mourad AssidiMarc-André Sirard
May 24, 2006·Microscopy Research and Technique·Eimei SatoJoh-E Ikeda
May 17, 2006·Microscopy Research and Technique·Stefania Annarita Nottola, Guido Macchiarelli
Dec 15, 2018·Molecular Reproduction and Development·Alejandra VelásquezLleretny Rodríguez-Álvarez
Mar 16, 2006·The Journal of Reproduction and Development·Jeremy G Thompson
Nov 29, 2008·Biology of Reproduction·Toshifumi TakahashiHirohisa Kurachi
Mar 15, 2015·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Eimei Sato
Aug 16, 2015·Reproductive Biology and Endocrinology : RB&E·Sheng-Hsiang LiRobert Kuo-Kuang Lee
Apr 16, 2019·Reproduction, Fertility, and Development·Marcelo T MouraRodolfo Rumpf
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Oct 31, 2015·Molecular Reproduction and Development·David H TaylorPaul D Soloway
Jun 29, 2011·Reproductive Medicine and Biology·Masaki Yokoo, Eimei Sato
Jun 4, 2017·Reproductive Biology and Endocrinology : RB&E·Joanna BudnaBartosz Kempisty
Oct 18, 2020·Molecular Biology Reports·Al-Shimaa Al-H H El-NabyAhmed A Farghali
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Feb 6, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Wen-Bin HeYue-Qiu Tan
Mar 10, 2009·Biochemical and Biophysical Research Communications·Woro Anindito Sri TunjungEimei Sato
Nov 9, 2021·Reproductive Sciences·Krutika PatilSrabani Mukherjee

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