Cupreous Complex-Loaded Chitosan Nanoparticles for Photothermal Therapy and Chemotherapy of Oral Epithelial Carcinoma

ACS Applied Materials & Interfaces
Min LinBai Yang

Abstract

Electron transition materials on the basis of transition metal ions usually possess higher photothermal transduction efficiency but lower extinction ability, which have not been considered as efficient photothermal agents for therapeutic applications. In this work, we demonstrate a facile and feasible approach for enhancing 808 nm photothermal conversion effect of d orbits transition Cu(II) ions by forming Cu-carboxylate complexes. The coordination with carboxylate groups greatly enlarges the splitting energy gap of Cu(II) and the capability of electron transition, thus enhancing the extinction ability in near-infrared region. The cupreous complexes are further loaded in biocompatible and biodegradable polymer nanoparticles (NPs) of chitosan to temporarily lower the toxicity, which allows the photothermal therapy of human oral epithelial carcinoma (KB) cells in vitro and KB tumors in vivo. Animal experiments indicate the photothermal tumor inhibition rate of 100%. In addition, the gradual degradation of chitosan NPs leads to the release of cupreous complexes, thus exhibiting additional chemotherapeutic behavior in KB tumor treatment. Onefold chemotherapy experiments indicate the tumor inhibition rate of 93.1%. The combination o...Continue Reading

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Citations

Oct 8, 2016·Advanced Materials·Zhengqing GuoHuabing Chen
Dec 23, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Xianxian YaoNobutaka Hanagata
Nov 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chuanqing Lan, Shulin Zhao
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria MercadanteAlessandro Poma
May 14, 2021·Bioinorganic Chemistry and Applications·Weiping ZhengChangqing Yuan
Aug 9, 2017·ACS Applied Materials & Interfaces·Radosław Mrówczyński
Dec 14, 2017·ACS Applied Materials & Interfaces·Shuwei LiuHao Zhang
May 28, 2020·ACS Applied Materials & Interfaces·Deepanjan GhoshKaushal Rege
Sep 27, 2019·Inorganic Chemistry·Jingmin WangHong Bi

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