Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus after Ischemia.

Cells
Woosuk KimIn Koo Hwang

Abstract

In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks. At six weeks after diet feeing, gerbils received transient forebrain ischemia with or without hypothermic preconditioning. Cuprizone treatment for 8 weeks increased the number of astrocytes, microglia, and pro-inflammatory cytokine levels in the hippocampus. In addition, cuprizone treatment significantly decreased the number of proliferating cells and neuroblasts in the dentate gyrus. Brain ischemia caused cell death, disruption of myelin basic proteins, and reactive gliosis in CA1. In addition, ischemia significantly increased pro-inflammatory cytokines and the number of proliferating cells and differentiating neuroblasts in the dentate gyrus. In contrast, hypothermic conditioning attenuated these changes in CA1 and the dentate gyrus. However, cuprizone treatment decreased cell survival induced by hypothermic preconditioning after ischemia and increased the number of reactive microglia and astrocytes in CA1 as well as that of macrophages in the subcallosal zone. These changes occurred bec...Continue Reading

References

Jan 1, 1984·Acta Neuropathologica·T Kirino, K Sano
Mar 3, 1997·Neuroreport·K Kumar, A T Evans
Oct 6, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C K PetitoW A Pulsinelli
May 22, 1998·Stroke; a Journal of Cerebral Circulation·T KurumataniM Takeda
Aug 28, 1998·Science·D R Green, J C Reed
Aug 13, 1999·Genes & Development·A GrossS J Korsmeyer
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masanori IwaiKoji Abe
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Feb 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Frederick ColbourneMichael V L Bennett
May 17, 2005·Immunity·Delu ZhouJanice S Blum
Jun 17, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robin J Lichtenwalner, Jack M Parent
Jun 22, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Era TaoufikLesley Probert
Apr 29, 2008·Brain Research Reviews·Megumi Sugahara KobayashiYasuo Takahashi
Nov 21, 2008·Journal of Neuroscience Research·Akvile NorkuteMarkus Kipp
Dec 10, 2008·Neurobiology of Disease·Carla M WebsterMidori A Yenari
Dec 17, 2008·Neuroscience Letters·Paraskevi N KoutsoudakiMartin Stangel
Oct 22, 2009·Anesthesia and Analgesia·Irina LasarzikKristin Engelhard
Jul 31, 2010·Neuron·Michael A MoskowitzCostantino Iadecola
Sep 4, 2010·Molecular Immunology·Sarah A IngersollBrian K Martin
Mar 3, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gergely Silasi, Frederick Colbourne
Mar 9, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vesna SelakovicLidija Radenovic
Aug 2, 2011·Current Cardiology Reviews·Ernest Palomeras Soler, Virgina Casado Ruiz
Feb 23, 2012·Nature Reviews. Neuroscience·Midori A Yenari, Hyung Soo Han
Mar 19, 2014·Biochimica Et Biophysica Acta·Hoon Jae JeongSoo Young Choi
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Jelle PraetPeter Ponsaerts

❮ Previous
Next ❯

Software Mentioned

ImageJ
Photoshop CC
OPTIMAS

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.