Cuprizone does not induce CNS demyelination in nonhuman primates

Annals of Clinical and Translational Neurology
Zhihong ChenBruce D Trapp

Abstract

Cognitive decline is a common symptom in multiple sclerosis patients, with profound effects on the quality of life. A nonhuman primate model of multiple sclerosis would be best suited to test the effects of demyelination on complex cognitive functions such as learning and reasoning. Cuprizone has been shown to reliably induce brain demyelination in mice. To establish a nonhuman primate model of multiple sclerosis, young adult cynomolgus monkeys were administered cuprizone per os as a dietary supplement. The subjects received increasing cuprizone doses (0.3-3% of diet) for up to 18 weeks. Magnetic resonance imaging and immunohistological analyses did not reveal demyelination in these monkeys.

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Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhihong ChenBruce D Trapp
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Daniel J MillerChet C Sherwood

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Citations

Jan 27, 2017·Neurotoxicity Research·Sandra HeckersMartin Stangel
Jul 18, 2017·Current Neuropharmacology·Jose M Vega-RiquerOscar Gonzalez-Perez
Feb 27, 2017·Journal of Molecular Neuroscience : MN·Tanja HochstrasserMarkus Kipp
Aug 24, 2019·Neuroscience and Biobehavioral Reviews·Monokesh K SenPeter J Shortland

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