Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis

Journal of Neuroimmunology
Vanessa HerderAndreas Beineke

Abstract

Multiple sclerosis is one of the most common demyelinating central nervous system diseases in young adults. Theiler's murine encephalomyelitis (TME) is a widely used virus-induced murine model for human myelin disorders. Immunosuppressive approaches generally reduce antiviral immunity and therefore increase virus dissemination with clinical worsening. In the present study, the progressive course of TME was significantly delayed due to a five-week cuprizone feeding period. Cuprizone was able to minimize demyelinating leukomyelitis without virus exacerbation. This phenomenon is supposed to be a consequence of selective inhibition of detrimental inflammatory responses with maintained protective immunity against the virus.

References

Jul 1, 1976·Journal of Comparative Pathology·R H Kimberlin, G C Millson
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KomolyC A Bondy
Aug 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Luisa M Salter-CidMatthew D Linnik
Aug 10, 2006·Journal of Neuropathology and Experimental Neurology·Reiner UlrichSusanne Alldinger
Nov 9, 2006·Experimental Brain Research·Leman MutluIngo Bechmann
Mar 30, 2007·Journal of Neural Transmission·A M O'RourkeM D Linnik
Aug 28, 2007·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Dirk SchaudienChristiane Herden
Oct 6, 2007·Nature Reviews. Immunology·Alan G Baxter
Mar 20, 2008·The American Journal of Pathology·Thomas SkripuletzMartin Stangel
Mar 25, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kidsadagon PringproaKonstantin Wewetzer
Dec 17, 2008·Neuroimmunomodulation·Isabelle HansenneVincent Geenen
Apr 18, 2009·Brain Pathology·Thomas SkripuletzMartin Stangel
Nov 7, 2009·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ikuo Tsunoda, Robert S Fujinami
Aug 12, 2010·Current Pharmaceutical Design·Makoto Naoi, Wakako Maruyama

❮ Previous
Next ❯

Citations

Nov 12, 2013·Veterinary Immunology and Immunopathology·V QeskaA Beineke
Sep 13, 2012·Journal of Neuroimmunology·I GerhauserW Baumgärtner
Feb 9, 2017·Journal of Neuropathology and Experimental Neurology·Viktoria GudiThomas Skripuletz
May 1, 2018·Journal of Molecular Neuroscience : MN·Nicole JungwirthFlorian Hansmann
Oct 9, 2015·Scientific Reports·Thomas SkripuletzMartin Stangel
May 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew V CaprarielloPeter K Stys
Mar 30, 2018·Frontiers in Immunology·Nellie A MartinZsolt Illes
Oct 30, 2020·Frontiers in Immunology·Monokesh K SenDavid A Mahns
Jul 3, 2021·International Journal of Molecular Sciences·Suvarin PavasutthipaisitAndreas Beineke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here