Cuprophan reuse and intradialytic changes of lung diffusion capacity and blood gases

Kidney International
R VanholderS M Ringoir

Abstract

The changes in arterial blood gas, pulmonary function tests, leukocyte counts and complement activation were evaluated during first use and subsequent reuse of cuprophan dialyzers. The dialysate buffer was bicarbonate. Reuse of cuprophan dialyzers significantly attenuated the fall in leukocyte counts and the rise in C3a des Arg seen during first use dialysis. First use dialysis also caused a drop in arterial paO2 from 93.0 +/- 12.4 mm Hg to a nadir of 82.8 +/- 12.6 mm Hg at 60 minutes (P less than 0.01). PaO2 levels did not change when reused dialyzers were employed (93.7 +/- 12.2 before dialysis and 96.4 +/- 15.2 mm Hg at 60 minutes, P greater than 0.05). Intradialytic paO2 curves obtained during first use and reuse were significantly different by variance analysis (P less than 0.001). There was also a significant decline in lung diffusion capacity (DLCO, from 30.70 +/- 8.89 to 23.77 +/- 7.76 ml/min X mm Hg, P less than 0.01) and transfer factor (KCO, from 6.07 +/- 1.97 to 5.65 +/- 2.13 ml/min X mm Hg, P less than 0.01), during first use at one hour after initiation of dialysis. This decrease was entirely prevented during reuse, (P less than 0.001 vs. first use by variance analysis). Percentual changes in leukocyte counts and ...Continue Reading

References

Oct 20, 1977·The New England Journal of Medicine·N M AurigemmaE G Lowrie
Oct 1, 1979·Archives of Internal Medicine·F Dumler, N W Levin
Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Apr 1, 1986·Kidney International·A K CheungL W Henderson
Mar 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G C FrancosD Gzesh
Jun 1, 1967·British Journal of Anaesthesia·G R KelmanR Greenbaum
Dec 1, 1983·Kidney International·D E ChenowethL W Henderson
Jul 9, 1981·The New England Journal of Medicine·M J DolanK Wasserman
May 1, 1981·Kidney International·K S KantR Berlin
May 1, 1983·Kidney International·W A De BackerM E De Broe
Oct 1, 1980·Kidney International·A I JacobJ J Bourgoignie

Citations

Jan 1, 1990·Respiratory Medicine·A Davenport, A J Williams
Jan 1, 1992·Biomaterials, Artificial Cells, and Immobilization Biotechnology : Official Journal of the International Society for Artificial Cells and Immobilization Biotechnology·G KolbK Havemann
Sep 1, 1989·Kidney International·J A DelmezD W Windus
Jul 1, 1993·Kidney International·R VanholderS M Ringoir
Dec 10, 1991·Clinical Materials·R Vanholder
May 21, 1998·Critical Reviews in Clinical Laboratory Sciences·B BaggioG Gambaro

Related Concepts

Cuprammonium cellulose
Blood Gas Analysis
Alphacel
Hemodialysis
Differential White Blood Cell Count Procedure
Lung
Membranes, Artificial
Respiratory Function Tests

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.