Curative effect of β-blocker on various ejection fractions of patients with atrial fibrillation

Experimental and Therapeutic Medicine
Wei Cao, Likun Ma

Abstract

The aim of this study was to retrospectively determine the effects of metoprolol on patients presenting with persistent atrial fibrillation (AF), but either with or without a reduced ejection fraction (EF). All patients meeting the inclusion criteria were treated for 2 years with metoprolol. Blood pressure, heart rate and echocardiography parameters were measured and analysed in patients before and after treatment. The patients were divided into 2 cohorts as follows: Those presenting with a low EF (<50%) and those with normal EF values (≥50%). In total, 151 patients enrolled were 136; however, of these 15 were lost to mortality during the follow-up period, thus leaving a total of 136 patients. In total, 42 patients presented EF values <50%, while the remaining 94 presented with normal EF values. Treatment with metoprolol controlled blood pressure (both diastolic and systolic) and heart rate in patients with both low and normal EF values. EF values in the low EF group significantly increased following treatment. In addition, the echocardiography data revealed a statistically significant decrease in left atrial and ventricular diameters in the low EF group. On the whole, the findings of this study demonstrate that patients with A...Continue Reading

References

Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Jul 9, 2010·Journal of Cardiac Failure·UNKNOWN Heart Failure Society of AmericaMary N Walsh
Sep 11, 2012·Congestive Heart Failure·Helme SilvetAlan K Jacobson
Sep 18, 2012·European Journal of Heart Failure·Kazuhiro YamamotoUNKNOWN J-DHF Investigators
Sep 7, 2014·Lancet·Dipak KotechaUNKNOWN Beta-Blockers in Heart Failure Collaborative Group
Dec 20, 2015·JACC. Heart Failure·Frank EdelmannUNKNOWN CIBIS-ELD Investigators and Project Multicenter Trials in the Competence Network Heart Failure
Jan 1, 2017·Revista Española De Cardiología·Paulus KirchhofPanagiotis Vardas
Feb 7, 2017·The American Journal of Medicine·Ohad Oren, Sheldon Goldberg

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02309398

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.